Evidence map›Paper›PMID 25145489›Full record

ArticleCancer2014

End-of-life treatment preferences: a key to reducing ethnic/racial disparities in advance care planning?

Melissa M Garrido, Shannon T Harrington, Holly G Prigerson

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04515810 (Planning Advance Care Together), which is not on this map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04515810 narecruitingnot on this mapstarted 2025, after this paper: background citation

Planning Advance Care Together (PACT) to Improve Engagement in Advance Care Planning

TypeinterventionalSponsorFred Hutchinson Cancer CenterRan2025 to 2027Enrolled400ConditionsLocally Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm, Recurrent Hematologic Malignancy, Refractory Hematologic MalignancyArmsInternet-Based Intervention, Best Practice, Telephone-Based Intervention, Questionnaire Administration, Post-intervention qualitative feedback interview
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
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  10. Review
  11. Racial and Ethnic Differences in Inpatient Palliative Care for Pediatric Stem Cell Transplant Patients.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2022
    Article
  12. Article
  13. "Don't Talk to Them About Goals of Care": Understanding Disparities in Advance Care Planning.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022
    Article
  14. Article
  15. Article
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  20. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Melissa M GarridoGeriatric Research, Education, and Clinical Center, James J. Peters Veterans Affairs Medical Center, New York, New York; Brookdale Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Shannon T Harrington
Holly G Prigerson
Cornell University · USIcahn School of Medicine at Mount Sinai · USUniversity of Massachusetts Boston · US

Funding

Clinical and Translational Science CenterUL1TR000457 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IMPERATO-MCGINLEY, JULIANNE L · 2012 to 2016
$46.0M
Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Albert C Shaw · 2002 to 2026
$37.9M
U Mass Boston / DFHCC U54 Partnership (1 of 2)U54CA156732 · NCI · DANA-FARBER CANCER INST · PI Nikhil Wagle · 2010 to 2026
$25.6M
Quality of Death: Ethnic and Psychosocial InfluencesR01CA106370 · NCI · YALE UNIVERSITY · PI PRIGERSON, HOLLY GWEN · 2004 to 2015
$4.1M
Impact of a Novel Cancer Communication Intervention on Caregiver BereavementR01CA168387 · NCI · UNIVERSITY OF ROCHESTER · PI DUBERSTEIN, PAUL R, PRIGERSON, HOLLY GWEN · 2013 to 2017
$2.6M
Psychiatric Disorder in Dying Patients &Their SurvivorsR01MH063892 · NIMH · YALE UNIVERSITY · PI JACOBS, SELBY C · 2002 to 2005
$1.9M
An Investigation of the Clinical Utility of a Prolonged Grief Disorder DiagnosisR21MH095378 · NIMH · SLOAN-KETTERING INST CAN RESEARCH · PI LICHTENTHAL, WENDY G., PRIGERSON, HOLLY GWEN · 2013 to 2014
$504k
Impact of Mental Illness on Veterans' Palliative Care Access and OutcomesIK2HX000767 · VA · JAMES J PETERS VA MEDICAL CENTER · PI GARRIDO, MELISSA M · 2014 to 2015
–
HSRD VA CDP 12-255HSRD VA IK2 HX000767NCATS NIH HHS UL1 TR000457NCI NIH HHS CA106370NCI NIH HHS CA156732NCI NIH HHS R01 CA106370NCI NIH HHS R01 CA168387NCI NIH HHS U54 CA156732NIA NIH HHS P30 AG021342NIMH NIH HHS MH63892NIMH NIH HHS R01 MH063892NIMH NIH HHS R21 MH095378
6 · The paper itself

Abstract

backgroundThe objective of this study was to identify targets for interventions to reduce end-of-life care disparities among patients with advanced cancer. To do this, the authors evaluated the degree to which end-of-life care values and preferences are associated with advance care planning within racial/ethnic minority groups.

methodsThe Coping with Cancer study recruited patients with advanced cancer from outpatient clinics in 5 states from 2002 to 2008. Then, the rates of 1 type of advance care planning-do-not-resuscitate (DNR) orders-reported at baseline interviews by 606 patients were investigated. Bivariate tests determined associations among DNR order completion, religious values, and treatment preferences within racial/ethnic groups.

resultsNon-Latino white patients were significantly more likely to have a DNR order (45%) than black (25%) and Latino (20%) patients (P<.001). A preference against specific life-prolonging treatment (eg, chemotherapy, ventilation) was the only factor significantly associated with higher DNR order likelihood in each group, with non-Latino white patients more likely than Latino or black patients to express preferences against life-prolonging care (eg, 26% of non-Latino white patients, 46% of black patients, and 41% of Latino patients wanted a feeding tube if it would extend life for 1 more day; P<.001).

conclusionsPreferences against life-prolonging care differ dramatically by race/ethnicity, but they have a uniform significant association with DNR order completion rates across racial/ethnic groups of patients with advanced cancer. Advance care planning interventions that target preferences associated with DNR orders across racial/ethnic groups may reach a broad patient population and reduce end-of-life care disparities.

Indexed as

Advance Care PlanningPatient PreferenceTerminal CareAdultAgedAttitude to DeathEthnicityFemaleHealthcare DisparitiesHumansMaleMiddle AgedNeoplasmsRacial Groupsadvance care planningcardiopulmonary resuscitationdo-not-resuscitate ordersend-of-life carehealth care disparities

Identifiers

PMID25145489
PMCPMC4257859
OpenAlexW1493892377

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.