Evidence map›Paper›PMID 25145434›Full record

ReviewFuture oncology (London, England)2014

Immunotherapy in pediatric malignancies: current status and future perspectives.

Christian M Capitini, Mario Otto, Kenneth B DeSantes, Paul M Sondel

Abstract readReview
In one paragraph

Review in Future oncology (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Commonly Reported Adverse Events Associated With Pediatric Immunotherapy: A Systematic Review From the Children's Oncology GroupJournal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses
    Pooled it
  2. Trial
  3. [Pediatric burkitt lymphoma primarily involving the adenoids: a case report and literature review].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Immunomodulatory Response Triggered by the Alkaloids, 3-Amino-7-Benzylbenzimidazo[3,2-Journal of cancer research and therapeutic oncology · 2015
    Article
  9. NK cell-based immunotherapies in Pediatric Oncology.Journal of pediatric hematology/oncology · 2015
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Christian M CapitiniDepartment of Pediatrics & Carbone Cancer Center, University of Wisconsin School of Medicine & Public Health, 1111 Highland Avenue, WIMR 4137, Madison, WI 53705, USA.
Mario Otto
Kenneth B DeSantes
Paul M Sondel
University of Wisconsin Carbone Cancer Center · US

Funding

THE IMMUNOBIOLOGY OF HUMAN ANTILEUKEMIC LYMPHOCYTESR01CA032685 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI SONDEL, PAUL M · 1985 to 2014
$4.3M
NCI NIH HHS R01 CA032685
6 · The paper itself

Abstract

Novel immune-based therapies are becoming available as additions to, and in some cases as alternatives to, the traditional treatment modalities such as chemotherapy, surgery and radiation that have improved outcomes for childhood cancer for decades. In this article, we will discuss what immunotherapies are being tested in the clinic, barriers to widespread application, and the future of immuno-oncology for childhood cancer. While in many cases, these therapies have shown dramatic responses in the setting of refractory or relapsed cancer, much remains to be learned about how to integrate these therapies into existing upfront regimens. The progress and challenges of developing immunotherapies for childhood cancer in a timely and cost-effective fashion will be discussed.

Indexed as

ImmunotherapyCancer VaccinesChildHumansNeoplasmsPediatricsCancer Vaccineschildhood cancerchimeric antigen receptorscytokinesimmunotherapymonoclonal antibodiesnatural killer cellsToll-like receptorsvaccines

Identifiers

PMID25145434
PMCPMC4793725
OpenAlexW2087599286

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.