Evidence map›Paper›PMID 25144711›Full record

ArticlePloS one2014

Association of CVD candidate gene polymorphisms with ischemic stroke and cerebral hemorrhage in Chinese individuals.

Wenjing Ou, Xin Liu, Yue Shen, Jiana Li, Lingbin He, Yuan Yuan, Xuerui Tan, Lisheng Liu, Jingbo Zhao, Xingyu Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 4 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 4 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. The MTHFR C677T Polymorphism and Risk of Intracerebral Hemorrhage in a Chinese Han Population.Medical science monitor : international medical journal of experimental and clinical research · 2016
    Pooled it
  5. Article
  6. Association of the methylenetetrahydrofolate reductase (The Journal of international medical research · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Wenjing OuDepartment of Epidemiology, Public Health School, Harbin Medical University, Heilongjiang, China; Department of Epidemiology, Public Health School, Harbin Medical University, Heilongjiang, China.
Xin LiuThe Laboratory of Human Genetics, Beijing Hypertension League Institute, Beijing, China.
Yue ShenThe Laboratory of Human Genetics, Beijing Hypertension League Institute, Beijing, China.
Jiana LiDepartment of Epidemiology, Public Health School, Harbin Medical University, Heilongjiang, China.
Lingbin HeFirst Affiliated Hospital, Medical College of Shantou University, Shantou, Guangdong, China.
Yuan YuanFirst Affiliated Hospital, Medical College of Shantou University, Shantou, Guangdong, China.
Xuerui TanFirst Affiliated Hospital, Medical College of Shantou University, Shantou, Guangdong, China.
Lisheng LiuThe Laboratory of Human Genetics, Beijing Hypertension League Institute, Beijing, China.
Jingbo ZhaoDepartment of Epidemiology, Public Health School, Harbin Medical University, Heilongjiang, China.
Xingyu WangFirst Affiliated Hospital, Medical College of Shantou University, Shantou, Guangdong, China; The Laboratory of Human Genetics, Beijing Hypertension League Institute, Beijing, China.
First Affiliated Hospital of Shantou University Medical College · CNHarbin Medical University · CNShanghai Institute of Hypertension · CNShantou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundContribution of cardiovascular disease related genetic risk factors for stroke are not clearly defined. We performed a genetic association study to assess the association of 56 previously characterized gene variants in 34 candidate genes from cardiovascular disease related biological pathways with ischemic stroke and cerebral hemorrhage in a Chinese population.

methodsThere were 1280 stroke patients (1101 with ischemic stroke and 179 with cerebral hemorrhage) and 1380 controls in the study. The genotypes for 56 polymorphisms of 34 candidate genes were determined by the immobilized probe approach and the associations of gene polymorphisms with ischemic stroke and cerebral hemorrhage were performed by logistic regression under an allelic model.

resultsAfter adjusting for age, sex, BMI and hypertension status by logistic regression analysis, we found that NPPA rs5063 was significantly associated with both ischemic stroke (odds ratio [OR] 0.69; 95% confidence interval [CI], 0.52 to 0.90; P = 0.006) and cerebral hemorrhage(OR = 0.39; 95%CI, 0.19 to 0.78; P = 0.007). In addition, MTHFR rs1801133 also was associated with cerebral hemorrhage (OR = 1.48; 95%CI, 1.16 to 1.89; P = 0.001) but not with ischemic stroke (OR = 1.08; 95%CI, 0.96 to 1.22; P = 0.210). After false discovery rate (FDR) correction, the association of NPPA rs5063 and MTHFR rs1801133 with cerebral hemorrhage remained significant.

conclusionsThe NPPA rs5063 is associated with reduced risk for cerebral hemorrhage and MTHFR rs1801133 is associated with increased risk of cerebral hemorrhage in a Chinese population.

Indexed as

Polymorphism, GeneticAgedCardiovascular DiseasesCase-Control StudiesCerebral HemorrhageChinaFemaleGenetic Association StudiesHumansMaleMiddle AgedPolymorphism, Single NucleotideRisk FactorsStroke

Identifiers

PMID25144711
PMCPMC4140791
OpenAlexW2121825556

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.