ArticlePloS one2014
Identification of urinary peptide biomarkers associated with rheumatoid arthritis.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Elucidation of a Human Urine Metabolite as a Seryl-Leucine Glycopeptide and as a Biomarker of Effective Anti-Tuberculosis Therapy.ACS infectious diseases · 2019Trial
- Urinary proteomic signature of exercise intolerance in patients at risk of heart failure: evidence from the HOMAGE trial.EBioMedicine · 2026Article
- Proteomic and glycosylation biomarkers in rheumatoid arthritis: advancing early diagnosis and precision therapy.Clinical proteomics · 2026Review
- Peptidome Profiling ofAntibiotics (Basel, Switzerland) · 2024Article
- Article
- Peptide profiling in cow urine reveals molecular signature of physiology-driven pathways and in-silico predicted bioactive properties.Scientific reports · 2021Article
- KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease.The Journal of clinical investigation · 2020Article
- Recombinant Human Plasma Gelsolin Stimulates Phagocytosis while Diminishing Excessive Inflammatory Responses in Mice withInternational journal of molecular sciences · 2020Article
- Plasma Gelsolin: Indicator of Inflammation and Its Potential as a Diagnostic Tool and Therapeutic Target.International journal of molecular sciences · 2018Review
- Urine peptidomic biomarkers for diagnosis of patients with systematic lupus erythematosus.Lupus · 2018Article
- Urinary peptidomics analysis reveals proteases involved in diabetic nephropathy.Scientific reports · 2017Article
- Stratified medicine in rheumatoid arthritis-the MATURA programme.Rheumatology (Oxford, England) · 2017Article
- CancerPDF: A repository of cancer-associated peptidome found in human biofluids.Scientific reports · 2017Article
- Urinary proteomics can define distinct diagnostic inflammatory arthritis subgroups.Scientific reports · 2017Article
- Article
- The Scottish Early Rheumatoid Arthritis (SERA) Study: an inception cohort and biobank.BMC musculoskeletal disorders · 2016Article
- Sequential high-content profiling of the IgG-autoantibody repertoire reveals novel antigens in rheumatoid arthritis.Arthritis research & therapy · 2016Article
- Current state of the art for enhancing urine biomarker discovery.Expert review of proteomics · 2016Review
- PEPstrMOD: structure prediction of peptides containing natural, non-natural and modified residues.Biology direct · 2015Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Early diagnosis and treatment of rheumatoid arthritis are associated with improved outcomes but current diagnostic tools such as rheumatoid factor or anti-citrullinated protein antibodies have shown limited sensitivity. In this pilot study we set out to establish a panel of urinary biomarkers associated with rheumatoid arthritis using capillary electrophoresis coupled to mass spectrometry. We compared the urinary proteome of 33 participants of the Scottish Early Rheumatoid Arthritis inception cohort study with 30 healthy controls and identified 292 potential rheumatoid arthritis-specific peptides. Amongst them, 39 were used to create a classifier model using support vector machine algorithms. Specific peptidic fragments were differentially excreted between groups; fragments of protein S100-A9 and gelsolin were less abundant in rheumatoid arthritis while fragments of uromodulin, complement C3 and fibrinogen were all increasingly excreted. The model generated was subsequently tested in an independent test-set of 31 samples. The classifier demonstrated a sensitivity of 88% and a specificity of 93% in diagnosing the condition, with an area under the receiver operating characteristic curve of 0.93 (p<0.0001). These preliminary results suggest that urinary biomarkers could be useful in the early diagnosis of rheumatoid arthritis. Further studies are currently being undertaken in larger cohorts of patients with rheumatoid arthritis and other athridities to assess the potential of the urinary peptide based classifier in the early detection of rheumatoid arthritis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.