Evidence map›Paper›PMID 25144625›Full record

Trial reportBritish journal of cancer2014

Subgroup effects in a randomised trial of different types and doses of exercise during breast cancer chemotherapy.

K S Courneya, D C McKenzie, J R Mackey, K Gelmon, C M Friedenreich, Y Yasui, R D Reid, J R Vallerand, S C Adams, C Proulx and 3 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02240836 (Energy Balance and Breast Cancer Aspects-II Study), which is not on this map. Cited by 38 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02240836 naactive not recruitingnot on this map

Energy Balance and Breast Cancer Aspects-II Study

TypeinterventionalSponsorOslo University HospitalRan2014 to 2027Enrolled545ConditionsDCIS Grade 3, Stage I Breast Cancer, Stage II Breast Cancer, LCIS, Lobular Carcinoma in SituArmsIntervention. Exercise
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Physical activity and pain in people with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  3. Body weight management in overweight and obese breast cancer survivors.The Cochrane database of systematic reviews · 2020
    Pooled it
  4. Resistance Training in Breast Cancer Survivors: A Systematic Review of Exercise Programs.International journal of environmental research and public health · 2020
    Pooled it
  5. Pooled it
  6. Aerobic exercise and cardiopulmonary fitness in childhood cancer survivors treated with a cardiotoxic agent: a meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018
    Pooled it
  7. Lending a hand: supportive exercise therapy for cancer treatment-induced polyneuropathy of the upper extremity-VISCIPH A.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Trial
  8. Pilot trial testing the effects of exercise on chemotherapy-induced peripheral neurotoxicity (CIPN) and the interoceptive brain system.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Trial
  9. Effects of exercise during chemotherapy on chemotherapy-induced peripheral neuropathy: a multicenter, randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018
    Trial
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  12. Trial
  13. Review
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  15. Observational
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

K S CourneyaFaculty of Physical Education and Recreation, University of Alberta, Edmonton, AB T6G 2H9, Canada.
D C McKenzieSchool of Kinesiology, University of British Columbia, Victoria, BC V6T 1Z1, Canada.
J R Mackey1] Department of Oncology, University of Alberta, Edmonton, AB T6G 1Z2, Canada [2] Cross Cancer Institute, Edmonton, AB T6G 1Z2, Canada.
K Gelmon1] Department of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada [2] Department of Medical Oncology, British Columbia Cancer Agency, Vancouver, BC V5Z 4E6, Canada.
C M FriedenreichDepartment of Cancer Epidemiology and Prevention Research, Alberta Health Services, Calgary, AB T2S 3C3, Canada.
Y YasuiSchool of Public Health, University of Alberta, Edmonton, AB T6G 1C9, Canada.
R D ReidDivision of Prevention and Rehabilitation, University of Ottawa Heart Institute, Ottawa, ON K1Y 4W7, Canada.
J R VallerandFaculty of Physical Education and Recreation, University of Alberta, Edmonton, AB T6G 2H9, Canada.
S C AdamsFaculty of Physical Education and Recreation, University of Alberta, Edmonton, AB T6G 2H9, Canada.
C ProulxDepartment of Medical Oncology, The Ottawa Hospital Cancer Center, Ottawa, ON K1H 8L8, Canada.
L B DolanSchool of Kinesiology, University of British Columbia, Victoria, BC V6T 1Z1, Canada.
E Wooding1] Department of Medical Oncology, The Ottawa Hospital Cancer Center, Ottawa, ON K1H 8L8, Canada [2] Ottawa Hospital Research Institute, Ottawa, ON K1Y 4E9, Canada.
R J Segal1] Department of Medical Oncology, The Ottawa Hospital Cancer Center, Ottawa, ON K1H 8L8, Canada [2] Ottawa Hospital Research Institute, Ottawa, ON K1Y 4E9, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Combined Aerobic and Resistance Exercise Trial tested different types and doses of exercise in breast cancer patients receiving chemotherapy. Here, we explore potential moderators of the exercise training responses.

methodsBreast cancer patients initiating chemotherapy (N=301) were randomly assigned to three times a week, supervised exercise of a standard dose of 25-30 min of aerobic exercise, a higher dose of 50-60 min of aerobic exercise, or a higher dose of 50-60 min of combined aerobic and resistance exercise. Outcomes were patient-reported symptoms and health-related fitness. Moderators were baseline demographic, exercise/fitness, and cancer variables.

resultsBody mass index moderated the effects of the exercise interventions on bodily pain (P for interaction=0.038), endocrine symptoms (P for interaction=0.029), taxane/neuropathy symptoms (P for interaction=0.013), aerobic fitness (P for interaction=0.041), muscular strength (P for interaction=0.007), and fat mass (P for interaction=0.005). In general, healthy weight patients responded better to the higher-dose exercise interventions than overweight/obese patients. Menopausal status, age, and baseline fitness moderated the effects on patient-reported symptoms. Premenopausal, younger, and fitter patients achieved greater benefits from the higher-dose exercise interventions.

conclusionsHealthy weight, fitter, and premenopausal/younger breast cancer patients receiving chemotherapy are more likely to benefit from higher-dose exercise interventions.

Indexed as

Quality of LifeAntineoplastic Combined Chemotherapy ProtocolsBreast NeoplasmsChemotherapy, AdjuvantExercise TherapyFemaleFollow-Up StudiesHumansMiddle AgedMotor ActivityPatient CompliancePrognosis

Identifiers

PMID25144625
PMCPMC4453726

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.