ArticleInhalation toxicology2014
The acute exposure effects of inhaled nickel nanoparticles on murine endothelial progenitor cells.
Article in Inhalation toxicology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- The pulmonary effects of nickel-containing nanoparticles: Cytotoxicity, genotoxicity, carcinogenicity, and their underlying mechanisms.Environmental science. Nano · 2024Article
- Tempol Preserves Endothelial Progenitor Cells in Male Mice with Ambient Fine Particulate Matter Exposure.Biomedicines · 2022Article
- Air Pollution Exposure Induces Vascular Injury and Hampers Endothelial Repair by Altering Progenitor and Stem Cells Functionality.Frontiers in cell and developmental biology · 2022Review
- Circulating Endothelial Progenitor Cells Are Preserved in Female Mice Exposed to Ambient Fine Particulate Matter Independent of Estrogen.International journal of molecular sciences · 2021Article
- Endothelial progenitor cells as critical mediators of environmental air pollution-induced cardiovascular toxicity.American journal of physiology. Heart and circulatory physiology · 2021Review
- Review and Evaluation of the Potential Health Effects of Oxidic Nickel Nanoparticles.Nanomaterials (Basel, Switzerland) · 2021Review
- Early Gestational Exposure to Inhaled Ozone Impairs Maternal Uterine Artery and Cardiac Function.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Inhalation of ZnO Nanoparticles: Splice Junction Expression and Alternative Splicing in Mice.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- Inhalation of Fine Particulate Matter Impairs Endothelial Progenitor Cell Function Via Pulmonary Oxidative Stress.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- Acute toxicological effects of zinc oxide nanoparticles in mice after intratracheal instillation.International journal of occupational and environmental health · 2017Article
- Metabolomic changes in murine serum following inhalation exposure to gasoline and diesel engine emissions.Inhalation toxicology · 2016Article
- Inflammatory and Vasoactive Effects of Serum Following Inhalation of Varied Complex Mixtures.Cardiovascular toxicology · 2016Article
- Metal rich particulate matter impairs acetylcholine-mediated vasorelaxation of microvessels in mice.Particle and fibre toxicology · 2015Article
- Inhalation toxicology methods: the generation and characterization of exposure atmospheres and inhalational exposures.Current protocols in toxicology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionThe discovery of endothelial progenitor cells (EPCs) may help to explain observed cardiovascular effects associated with inhaled nickel nanoparticle exposures, such as increases in vascular inflammation, generation of reactive oxygen species, altered vasomotor tone and potentiated atherosclerosis in murine species.
methodsFollowing an acute whole body inhalation exposure to 500 µg/m(3) of nickel nanoparticles for 5 h, bone marrow EPCs from C57BL/6 mice were isolated. EPCs were harvested for their RNA or used in a variety of assays including chemotaxis, tube formation and proliferation. Gene expression was assessed for important receptors involved in EPC mobilization and homing using RT-PCR methods. EPCs, circulating endothelial progenitor cells (CEPCs), circulating endothelial cells (CECs) and endothelial microparticles (EMPs) were quantified on a BD FACSCalibur to examine endothelial damage and repair associated with the exposure. RESULTS AND
conclusionsAcute exposure to inhaled nickel nanoparticles significantly increased both bone marrow EPCs as well as their levels in circulation (CEPCs). CECs were significantly elevated indicating that endothelial damage occurred due to the exposure. There was no significant difference in EMPs between the two groups. Tube formation and chemotaxis, but not proliferation, of bone marrow EPCs was impaired in the nickel nanoparticle exposed group. These results coincided with a decrease in the mRNA of receptors involved in EPC mobilization and homing. These data provide new insight into how an acute nickel nanoparticle exposure to half of the current Occupational Safety & Health Administration (OSHA) permissible exposure limit may adversely affect EPCs and exacerbate cardiovascular disease states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.