ArticlePLoS pathogens2014
NLR-associating transcription factor bHLH84 and its paralogs function redundantly in plant immunity.
Article in PLoS pathogens, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 80 citations in OpenAlex.
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- Soybean transcription factors GmHSF-01 and GmNF-YC03 regulate the GmSRC7BMC plant biology · 2026Article
- A KNOX Ⅱ transcription factor suppresses the NLR immune receptor BRG8-mediated immunity in rice.Plant communications · 2024Article
- Unveiling the Role of RNA Recognition Motif Proteins in Orchestrating Nucleotide-Binding Site and Leucine-Rich Repeat Protein Gene Pairs and Chloroplast Immunity Pathways: Insights into Plant Defense Mechanisms.International journal of molecular sciences · 2024Article
- Constitutive Overexpression of an NB-ARC Gene from Wild ChineseInternational journal of molecular sciences · 2024Article
- Comparison of Transcriptome between Tolerant and Susceptible Rice Cultivar Reveals Positive and Negative Regulators of Response toInternational journal of molecular sciences · 2023Article
- The Arabidopsis thaliana onset of leaf death 12 mutation in the lectin receptor kinase P2K2 results in an autoimmune phenotype.BMC plant biology · 2023Article
- Fine mapping of a Fusarium crown rot resistant locus on chromosome arm 6HL in barley by exploiting near isogenic lines, transcriptome profiling, and a large near isogenic line-derived population.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Advances in Biological Control and Resistance Genes of Brassicaceae Clubroot Disease-The Study Case of China.International journal of molecular sciences · 2023Review
- Loss of function of the bHLH transcription factor Nrd1 in tomato enhances resistance to Pseudomonas syringae.Plant physiology · 2022Article
- An interolog-based barley interactome as an integration framework for immune signaling.Genetics · 2022Article
- A fungal effector suppresses the nuclear export of AGO1-miRNA complex to promote infection in plants.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- A cluster of atypical resistance genes in soybean confers broad-spectrum antiviral activity.Plant physiology · 2022Article
- Interactome of Arabidopsis Thaliana.Plants (Basel, Switzerland) · 2022Article
- Perception of structurally distinct effectors by the integrated WRKY domain of a plant immune receptor.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Recent Advances in Effector-Triggered Immunity in Plants: New Pieces in the Puzzle Create a Different Paradigm.International journal of molecular sciences · 2021Review
- Nucleocytoplasmic Communication in Healthy and Diseased Plant Tissues.Frontiers in plant science · 2021Review
- Recent Findings Unravel Genes and Genetic Factors UnderlyingInternational journal of molecular sciences · 2020Review
- Transcriptional analyses of differential cultivars during resistant and susceptible interactions with Peronospora effusa, the causal agent of spinach downy mildew.Scientific reports · 2020Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
In plants and animals, nucleotide-binding and leucine-rich repeat domain containing (NLR) immune receptors are utilized to detect the presence or activities of pathogen-derived molecules. However, the mechanisms by which NLR proteins induce defense responses remain unclear. Here, we report the characterization of one basic Helix-loop-Helix (bHLH) type transcription factor (TF), bHLH84, identified from a reverse genetic screen. It functions as a transcriptional activator that enhances the autoimmunity of NLR mutant snc1 (suppressor of npr1-1, constitutive 1) and confers enhanced immunity in wild-type backgrounds when overexpressed. Simultaneously knocking out three closely related bHLH paralogs attenuates RPS4-mediated immunity and partially suppresses the autoimmune phenotypes of snc1, while overexpression of the other two close paralogs also renders strong autoimmunity, suggesting functional redundancy in the gene family. Intriguingly, the autoimmunity conferred by bHLH84 overexpression can be largely suppressed by the loss-of-function snc1-r1 mutation, suggesting that SNC1 is required for its proper function. In planta co-immunoprecipitation revealed interactions between not only bHLH84 and SNC1, but also bHLH84 and RPS4, indicating that bHLH84 associates with these NLRs. Together with previous finding that SNC1 associates with repressor TPR1 to repress negative regulators, we hypothesize that nuclear NLR proteins may interact with both transcriptional repressors and activators during immune responses, enabling potentially faster and more robust transcriptional reprogramming upon pathogen recognition.
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