ArticleJournal of perinatology : official journal of the California Perinatal Association2014
Short-term outcomes for preterm infants with surgical necrotizing enterocolitis.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Empirical Antimicrobial Therapy of Neonates with Necrotizing Enterocolitis: A Systematic Review.American journal of perinatology · 2023Pooled it
- Are Immune Modulating Single Nucleotide Polymorphisms Associated with Necrotizing Enterocolitis?Scientific reports · 2015Trial
- Comparison of imaging findings of surgical necrotizing enterocolitis between extremely preterm and preterm infants.Pediatric radiology · 2026Article
- Is Necrotizing Enterocolitis Totalis a Distinct Disease Process?Pediatric gastroenterology, hepatology & nutrition · 2026Article
- Risk Factors for 30-day Mortality in Patients with Surgically Treated Necrotizing Enterocolitis: A Multicenter Retrospective Cohort Study.European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie · 2025Article
- International Comparison of Surgical Management Practices for Necrotizing Enterocolitis in Neonates: Insights from Cohorts in the Netherlands and Finland.European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie · 2025Article
- Initial surgery for spontaneous intestinal perforation in extremely low birth weight infants is not associated with mortality or in-hospital morbidities.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Gut microbiota differences in five-year-old children that were born preterm with a history of necrotizing enterocolitis: A pilot trial.iScience · 2024Article
- Association of Hospital Resource Utilization With Neurodevelopmental Outcomes in Neonates With Hypoxic-Ischemic Encephalopathy.JAMA network open · 2023Article
- Long-term outcomes and life-impacts of necrotizing enterocolitis: A survey of survivors and parents.Seminars in perinatology · 2023Article
- Survey of UK clinicians' approaches to decision making in neonatal intestinal failure.Frontline gastroenterology · 2023Article
- Value of abdominal ultrasonography in predicting intestinal resection for premature infants with necrotizing enterocolitis.BMC gastroenterology · 2022Review
- Effect of selective gastric residual monitoring on enteral intake in preterm infants.Italian journal of pediatrics · 2022Article
- Prenatal administration of heparin-binding epidermal growth factor-like growth factor in an experimental model of necrotizing enterocolitis decreased both incidence and severity of the disease.World journal of pediatric surgery · 2022Article
- Neurodevelopmental and Growth Outcomes of Extremely Preterm Infants with Short Bowel Syndrome.The Journal of pediatrics · 2021Article
- Necrotizing Enterocolitis: LPS/TLR4-Induced Crosstalk Between Canonical TGF-β/Wnt/β-Catenin Pathways and PPARγ.Frontiers in pediatrics · 2021Review
- Survey on antibiotic regimens for necrotizing enterocolitis prescribed by Chinese pediatricians in 2020.World journal of pediatric surgery · 2021Article
- Prenatal Immunity and Influences on Necrotizing Enterocolitis and Associated Neonatal Disorders.Frontiers in immunology · 2021Review
- Precision-based modeling approaches for necrotizing enterocolitis.Disease models & mechanisms · 2020Review
Corrections and comments
- Commented on by
Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo characterize the population and short-term outcomes in preterm infants with surgical necrotizing enterocolitis (NEC). STUDY
designPreterm infants with surgical NEC were identified from 27 hospitals over 3 years using the Children's Hospitals Neonatal Database; infants with gastroschisis, volvulus, major congenital heart disease or surgical NEC that resolved prior to referral were excluded. Patient characteristics and pre-discharge morbidities were stratified by gestational age (<28 vs 28(0/7) to 36(6/7) weeks' gestation).
resultOf the 753 eligible infants, 60% were born at <28 weeks' gestation. The median age at referral was 14 days; only 2 infants were inborn. Male gender (61%) was overrepresented, whereas antenatal steroid exposure was low (46%). Although only 11% had NEC totalis, hospital mortality (<28 weeks' gestation: 41%; 28(0/7) to 36(6/7) weeks' gestation: 32%, P=0.02), short bowel syndrome (SBS)/intestinal failure (IF) (20% vs 26%, P=0.06) and the composite of mortality or SBS/IF (50% vs 49%, P=0.7) were prevalent. Also, white matter injury (11.7% vs 6.6%, P=0.02) and grade 3 to 4 intraventricular hemorrhages (23% vs 2.7%, P<0.01) were commonly diagnosed. After referral, the median length of hospitalization was longer for survivors (106 days; interquartile range (IQR) 79, 152) relative to non-survivors (2 days; IQR 1,17; P<0.001). These survivors were prescribed parenteral nutrition infrequently after hospital discharge (<28 weeks': 5.2%; 28(0/7) to 36(6/7) weeks': 9.9%, P=0.048).
conclusionAfter referral for surgical NEC, the short-term outcomes are grave, particularly for infants born <28 weeks' gestation. Although analyses to predict outcomes are urgently needed, these data suggest that affected infants are at a high risk for lengthy hospitalizations and adverse medical and neuro-developmental abnormalities.
Indexed as
Identifiers
25144157What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.