ReviewBioMed research international2014
A review of bioactive release from nerve conduits as a neurotherapeutic strategy for neuronal growth in peripheral nerve injury.
Review in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Stimulation Based Drug Release From Dual-Layered Microspheres.Macromolecular bioscience · 2026Article
- Case Report: Regenerative peptides for Inferior alveolar nerve injury: a narrative review with hypothesis-generating three clinical cases.Frontiers in oral health · 2026Article
- A process optimization and release modeling of coaxial electrospun aligned core-shell poly (ethylene oxide-poly(l-lactide-co-glycolide)) nanofibers encapsulating nerve growth factor.Journal of applied polymer science · 2025Article
- Enhancing peripheral nerve regeneration with rehabilitation and biomaterial-driven drug delivery strategies.Progress in biomedical engineering (Bristol, England) · 2025Review
- The role of Genipin crosslinked extracellular matrix loaded bFGF in the repair of peripheral nerve injury.BMC biotechnology · 2025Article
- Mesoporous Prussian blue nanoparticle neuroconduit for the biological therapy targeting oxidative stress reduction, inflammation inhibition, and nerve regeneration.Journal of nanobiotechnology · 2025Article
- Design and Development of a Polymeric-Based Curcumin Nanoparticle for Drug Delivery Enhancement and Potential Incorporation into Nerve Conduits.Molecules (Basel, Switzerland) · 2024Article
- Updates in peripheral nerve surgery of the upper extremity: diagnosis and treatment options.Annals of translational medicine · 2023Review
- Development and preclinical evaluation of bioactive nerve conduits for peripheral nerve regeneration: A comparative study.Materials today. Bio · 2023Article
- Advances in Biomimetic Nerve Guidance Conduits for Peripheral Nerve Regeneration.Nanomaterials (Basel, Switzerland) · 2023Review
- Recent Advances in Polymeric Drug Delivery Systems for Peripheral Nerve Regeneration.Pharmaceutics · 2023Review
- Investigations into the effects of scaffold microstructure on slow-release system with bioactive factors for bone repair.Frontiers in bioengineering and biotechnology · 2023Review
- Effect of 3D Printing Temperature on Bioactivity of Bone Morphogenetic Protein-2 Released from Polymeric Constructs.Annals of biomedical engineering · 2021Article
- Machine intelligence for nerve conduit design and production.Journal of biological engineering · 2020Review
- Current concepts in peripheral nerve surgery.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2019Review
- Effect Of combining FK506 and neurotrophins on neurite branching and elongation.Muscle & nerve · 2017Article
- Approaches to Peripheral Nerve Repair: Generations of Biomaterial Conduits Yielding to Replacing Autologous Nerve Grafts in Craniomaxillofacial Surgery.BioMed research international · 2016Review
- Potential of the use of an antioxidant compound to promote peripheral nerve regeneration after injury.Neural regeneration research · 2015Article
- Nerve autografts and tissue-engineered materials for the repair of peripheral nerve injuries: a 5-year bibliometric analysis.Neural regeneration research · 2015Article
- Past, Present, and Future of Nerve Conduits in the Treatment of Peripheral Nerve Injury.BioMed research international · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peripheral nerve regeneration strategies employ the use of polymeric engineered nerve conduits encompassed with components of a delivery system. This allows for the controlled and sustained release of neurotrophic growth factors for the enhancement of the innate regenerative capacity of the injured nerves. This review article focuses on the delivery of neurotrophic factors (NTFs) and the importance of the parameters that control release kinetics in the delivery of optimal quantities of NTFs for improved therapeutic effect and prevention of dose dumping. Studies utilizing various controlled-release strategies, in attempt to obtain ideal release kinetics, have been reviewed in this paper. Release strategies discussed include affinity-based models, crosslinking techniques, and layer-by-layer technologies. Currently available synthetic hollow nerve conduits, an alternative to the nerve autografts, have proven to be successful in the bridging and regeneration of primarily the short transected nerve gaps in several patient cases. However, current research emphasizes on the development of more advanced nerve conduits able to simulate the effectiveness of the autograft which includes, in particular, the ability to deliver growth factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.