Evidence map›Paper›PMID 25143830›Full record

Trial reportJournal of obesity2014

Using the Medical Research Council framework for the development and evaluation of complex interventions in a theory-based infant feeding intervention to prevent childhood obesity: the baby milk intervention and trial.

Rajalakshmi Lakshman, Simon Griffin, Wendy Hardeman, Annie Schiff, Ann Louise Kinmonth, Ken K Ong

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of obesity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Rajalakshmi LakshmanMRC Epidemiology Unit, University of Cambridge, Addenbrooke's Hospital, P.O. Box 285, Cambridge CB2 0QQ, UK ; UKCRC Centre for Diet and Activity Research, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0001-6748-5960
Simon GriffinMRC Epidemiology Unit, University of Cambridge, Addenbrooke's Hospital, P.O. Box 285, Cambridge CB2 0QQ, UK ; UKCRC Centre for Diet and Activity Research, University of Cambridge, Cambridge CB2 0QQ, UK ; The Primary Care Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB2 0SR, UK.
Wendy HardemanThe Primary Care Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB2 0SR, UK.
Annie SchiffUKCRC Centre for Diet and Activity Research, University of Cambridge, Cambridge CB2 0QQ, UK.ORCID 0000-0002-6745-9954
Ann Louise KinmonthThe Primary Care Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB2 0SR, UK.
Ken K OngMRC Epidemiology Unit, University of Cambridge, Addenbrooke's Hospital, P.O. Box 285, Cambridge CB2 0QQ, UK ; Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK.
University of Cambridge · GB

Funding

Biotechnology and Biological Sciences Research CouncilBritish Heart FoundationCancer Research UKChief Scientist OfficeDepartment of HealthMedical Research Council G0200391Medical Research Council G070165Medical Research Council MC_EX_G0701655Medical Research Council MC_EX_MR/J000361/1Medical Research Council MC_EX_UU_MR/J000361/1Medical Research Council MC_U106179472Medical Research Council MC_U106179474Medical Research Council MC_UU_12015/2Medical Research Council MC_UU_12015/4Medical Research Council MR/J000361/1Medical Research Council MR/K023187/1Wellcome Trust
6 · The paper itself

Abstract

introductionWe describe our experience of using the Medical Research Council framework on complex interventions to guide the development and evaluation of an intervention to prevent obesity by modifying infant feeding behaviours.

methodsWe reviewed the epidemiological evidence on early life risk factors for obesity and interventions to prevent obesity in this age group. The review suggested prevention of excess weight gain in bottle-fed babies and appropriate weaning as intervention targets; hence we undertook systematic reviews to further our understanding of these behaviours. We chose theory and behaviour change techniques that demonstrated evidence of effectiveness in altering dietary behaviours. We subsequently developed intervention materials and evaluation tools and conducted qualitative studies with mothers (intervention recipients) and healthcare professionals (intervention deliverers) to refine them. We developed a questionnaire to assess maternal attitudes and feeding practices to understand the mechanism of any intervention effects.

conclusionsIn addition to informing development of our specific intervention and evaluation materials, use of the Medical Research Council framework has helped to build a generalisable evidence base for early life nutritional interventions. However, the process is resource intensive and prolonged, and this should be taken into account by public health research funders. This trial is registered with ISRTCN: 20814693 Baby Milk Trial.

Indexed as

Health BehaviorInfant Nutritional Physiological PhenomenaMothersAdultBiomedical ResearchFeasibility StudiesFeeding BehaviorFemaleHealth Knowledge, Attitudes, PracticeHumansInfantInfant, NewbornMaleParentingPediatric ObesityPregnancy

Identifiers

PMID25143830
PMCPMC4131118
OpenAlexW2141211931

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.