ArticleAnnals of dermatology2014
Comparison of Melanoma Subtypes among Korean Patients by Morphologic Features and Ultraviolet Exposure.
Article in Annals of dermatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Trial
- Genomic profiling and therapeutic targets of Thai melanoma revealed by next-generation sequencing.Scientific reports · 2026Article
- Standardized Incidence Ratio of Melanoma by Industry Groups in Korea.Safety and health at work · 2025Article
- Association between Ki-67 and clinical outcomes in 324 Chinese patients with resectable acral melanoma.Scientific reports · 2025Article
- Modelling Acral Melanoma in Admixed Brazilians Uncovers Genomic Drivers and Targetable Pathways.medRxiv : the preprint server for health sciences · 2025Article
- Rosacea is strongly associated with melanoma in Caucasians.Scientific reports · 2024Article
- Skin cancer risk of menopausal hormone therapy in a Korean cohort.Scientific reports · 2023Article
- Risk of Skin Cancer and Actinic Keratosis in Patients with Rosacea: A Nationwide Population-based Cohort Study.Acta dermato-venereologica · 2022Article
- Acral Melanocytic Neoplasms: A Comprehensive Review of Acral Nevus and Acral Melanoma in Asian Perspective.Dermatopathology (Basel, Switzerland) · 2022Review
- Weight-bearing activity impairs nuclear membrane and genome integrity via YAP activation in plantar melanoma.Nature communications · 2022Article
- A Case Report of Spitzoid Melanoma in a Patient with Breast Cancer.Annals of dermatology · 2022Article
- Article
- Acral lentiginous melanoma: Basic facts, biological characteristics and research perspectives of an understudied disease.Pigment cell & melanoma research · 2021Review
- Effect of Treatment with the PD-1/PD-L1 Inhibitors on Key Health Outcomes of Cancer Patients.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2021Article
- Comprehensive molecular and clinical characterization of Asian melanoma patients treated with anti-PD-1 antibody.BMC cancer · 2019Article
- An updated review of mucosal melanoma: Survival meta-analysis.Molecular and clinical oncology · 2019Article
- Clinicopathologic Features and Prognostic Factors of Primary Cutaneous Melanoma: a Multicenter Study in Korea.Journal of Korean medical science · 2019Article
- Clinical spectrum of cutaneous melanoma morphology.Journal of the American Academy of Dermatology · 2019Article
- Ipilimumab Real-World Efficacy and Safety in Korean Melanoma Patients from the Korean Named-Patient Program Cohort.Cancer research and treatment · 2017Article
- Genetic Characteristics of Primary Cutaneous Malignant Melanoma in Koreans Compared With Western Populations.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGenetic alterations have been identified in melanomas according to different levels of sun exposure. Whereas the conventional morphology-based classification provides a clue for tumor growth and prognosis, the new classification by genetic alterations offers a basis for targeted therapy.
objectiveThe purpose of this study is to demonstrate the biological behavior of melanoma subtypes and compare the two classifications in the Korean population.
methodsA retrospective chart review was performed on patients found to have malignant melanoma in Severance Hospital from 2005 to 2012. Age, sex, location of the tumor, histologic subtype, tumor depth, ulceration, lymph node invasion, visceral organ metastasis, and overall survival were evaluated.
resultsOf the 206 cases, the most common type was acral melanoma (n=94, 45.6%), followed by nonchronic sun damage-induced melanoma (n=43, 20.9%), and mucosal melanoma (n=40, 19.4%). Twenty-one patients (10.2%) had the chronic sun-damaged type, whereas eight patients (3.9%) had tumors of unknown primary origin. Lentigo maligna melanoma was newly classified as the chronic sun-damaged type, and acral lentiginous melanoma as the acral type. More than half of the superficial spreading melanomas were newly grouped as nonchronic sun-damaged melanomas, whereas nodular melanoma was rather evenly distributed.
conclusionThe distribution of melanomas was largely similar in both the morphology-based and sun exposure-based classifications, and in both classifications, mucosal melanoma had the worst 5-year survival owing to its tumor thickness and advanced stage at the time of diagnosis.
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