ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Distinct roles of bulbar muscarinic and nicotinic receptors in olfactory discrimination learning.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 41 citations in OpenAlex.
- Deletion of NPAS4 in olfactory bulb principal neurons alters E/I balance and impairs decoding of chemically similar odour molecules.The Journal of physiology · 2026Article
- Vulnerability of long-range inputome of basal forebrain in normal aging mice.Frontiers in aging neuroscience · 2025Article
- Basal Forebrain-Dorsal Hippocampus Cholinergic Circuit Regulates Olfactory Associative Learning.International journal of molecular sciences · 2022Article
- Article
- The Response Dynamics and Function of Cholinergic and GABAergic Neurons in the Basal Forebrain During Olfactory Learning.Frontiers in cellular neuroscience · 2022Article
- Modulation of Neural Microcircuits That Control Complex Dynamics in Olfactory Networks.Frontiers in cellular neuroscience · 2021Article
- Noradrenergic Activity in the Olfactory Bulb Is a Key Element for the Stability of Olfactory Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Experience enhances certainty about olfactory stimuli under bulbar cholinergic control.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Context-dependent odor learning requires the anterior olfactory nucleus.Behavioral neuroscience · 2020Article
- Cortical Organization of Centrifugal Afferents to the Olfactory Bulb: Mono- and Trans-synaptic Tracing with Recombinant Neurotropic Viral Tracers.Neuroscience bulletin · 2019Article
- Basal forebrain GABAergic innervation of olfactory bulb periglomerular interneurons.The Journal of physiology · 2019Article
- Olfactory Bulb Muscarinic Acetylcholine Type 1 Receptors Are Required for Acquisition of Olfactory Fear Learning.Frontiers in behavioral neuroscience · 2019Article
- Hibernation Impairs Odor Discrimination - Implications for Alzheimer's Disease.Frontiers in neuroanatomy · 2019Article
- A dominant role for the beta 4 nicotinic receptor subunit in nicotinic modulation of glomerular microcircuits in the mouse olfactory bulb.Journal of neurophysiology · 2018Article
- Different Subgroups of Cholinergic Neurons in the Basal Forebrain Are Distinctly Innervated by the Olfactory Regions and Activated Differentially in Olfactory Memory Retrieval.Frontiers in neural circuits · 2018Article
- Main Plant Extracts' Active Properties Effective on Scopolamine-Induced Memory Loss.American journal of Alzheimer's disease and other dementias · 2017Review
- Layer- and cell type-selective co-transmission by a basal forebrain cholinergic projection to the olfactory bulb.Nature communications · 2017Article
- Interaction between age and perceptual similarity in olfactory discrimination learning in F344 rats: relationships with spatial learning.Neurobiology of aging · 2017Article
- Dichotomous Distribution of Putative Cholinergic Interneurons in Mouse Accessory Olfactory Bulb.Frontiers in neuroanatomy · 2017Article
- Discrimination performance in aging is vulnerable to interference and dissociable from spatial memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The olfactory bulb (OB) and piriform cortex receive dense cholinergic projections from the basal forebrain. Cholinergic modulation within the piriform cortex has long been proposed to serve important functions in olfactory learning and memory. We here investigate how olfactory discrimination learning is regulated by cholinergic modulation of the OB inputs to the piriform cortex. We examined rats' performance on a two-alternative choice odor discrimination task following local, bilateral blockade of cholinergic nicotinic and/or muscarinic receptors in the OB. Results demonstrate that acquisition, but not recall, of novel discrimination problems is impaired following blockade of OB cholinergic receptors, although the relative contribution of muscarinic and nicotinic receptors depends on task difficulty. Blocking muscarinic receptors impairs learning for nearly all odor sets, whereas blocking nicotinic receptors only affects performance for perceptually similar odors. This pattern of behavioral effects is consistent with predictions from a model of cholinergic modulation in the OB and piriform cortex (de Almeida et al., 2013). Model simulations suggest that muscarinic and nicotinic receptors may serve complementary roles in regulating coherence and sparseness of the OB network output, which in turn differentially regulate the strength and overlap in cortical odor representations. Overall, our results suggest that muscarinic receptor blockade results in a bona fide learning impairment that may arise because cortical neurons are activated less often. Behavioral impairment following nicotinic receptor blockade may not be due to the inability of the cortex to learn, but rather arises because the cortex is unable to resolve highly overlapping input patterns.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.