ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Chromophore supply rate-limits mammalian photoreceptor dark adaptation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 27 citations in OpenAlex.
- Nr2e3-Deficient Mice Show Evidence for Elevated Photoreceptor Bioenergetics and Retinal Visual Cycle Activity Based on OCT Metabolic Biomarkers.Investigative ophthalmology & visual science · 2026Article
- Article
- Germline knockout ofProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia.Cell reports · 2023Article
- Investigating the Role of RhodopsineNeuro · 2023Article
- Dark Adaptation and Its Role in Age-Related Macular Degeneration.Journal of clinical medicine · 2022Review
- Delayed dark adaptation in central serous chorioretinopathy.American journal of ophthalmology case reports · 2021Article
- Mislocalization of cone nuclei impairs cone function in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Light-Driven Regeneration of Cone Visual Pigments through a Mechanism Involving RGR Opsin in Müller Glial Cells.Neuron · 2019Article
- Apo-Opsin Exists in Equilibrium Between a Predominant Inactive and a Rare Highly Active State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- GUCY2D Cone-Rod Dystrophy-6 Is a "Phototransduction Disease" Triggered by Abnormal Calcium Feedback on Retinal Membrane Guanylyl Cyclase 1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Electrophysiological Studies on The Dynamics of Luminance Adaptation in the Mouse Retina.Vision (Basel, Switzerland) · 2017Article
- The role of retinol dehydrogenase 10 in the cone visual cycle.Scientific reports · 2017Article
- The retina visual cycle is driven by cis retinol oxidation in the outer segments of cones.Visual neuroscience · 2017Article
- cis Retinol oxidation regulates photoreceptor access to the retina visual cycle and cone pigment regeneration.The Journal of physiology · 2016Article
- Rhodopsin kinase and arrestin binding control the decay of photoactivated rhodopsin and dark adaptation of mouse rods.The Journal of general physiology · 2016Article
- The B3 Subunit of the Cone Cyclic Nucleotide-gated Channel Regulates the Light Responses of Cones and Contributes to the Channel Structural Flexibility.The Journal of biological chemistry · 2016Article
- Delayed Rod-Mediated Dark Adaptation Is a Functional Biomarker for Incident Early Age-Related Macular Degeneration.Ophthalmology · 2016Article
- Measurement of Electroretinograms and Visually Evoked Potentials in Awake Moving Mice.PloS one · 2016Article
- Circadian and light-driven regulation of rod dark adaptation.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Efficient regeneration of visual pigment following its destruction by light is critical for the function of mammalian photoreceptors. Here, we show that misexpression of a subset of cone genes in the rd7 mouse hybrid rods enables them to access the normally cone-specific retina visual cycle. The rapid supply of chromophore by the retina visual cycle dramatically accelerated the mouse rod dark adaptation. At the same time, the competition between rods and cones for retina-derived chromophore slowed cone dark adaptation, indicating that the cone specificity of the retina visual cycle is key for rapid cone dark adaptation. Our findings demonstrate that mammalian photoreceptor dark adaptation is dominated by the supply of chromophore. Misexpression of cone genes in rods may represent a novel approach to treating visual disorders associated with mutations of visual cycle proteins or with reduced retinal pigment epithelium function due to aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.