ArticleJournal of clinical microbiology2014
Major intercontinentally distributed sequence types of Kingella kingae and development of a rapid molecular typing tool.
Article in Journal of clinical microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Fastidious or rarely isolated gram-negative rods with a particular focus onClinical microbiology reviews · 2025Review
- Article
- Infective Endocarditis Due toMicroorganisms · 2024Review
- Acquisition, co-option, and duplication of the rtx toxin system and the emergence of virulence in Kingella.Nature communications · 2023Article
- Whole-Genome Sequencing Reveals Differences among Kingella kingae Strains from Carriers and Patients with Invasive Infections.Microbiology spectrum · 2023Article
- Pharyngeal Colonization byMicroorganisms · 2022Review
- Pathogenic determinants ofFrontiers in pediatrics · 2022Review
- First report ofThe Pan African medical journal · 2022Article
- Detection of Respiratory Colonization by Kingella kingae and the Novel Kingella negevensis Species in Children: Uses and Methodology.Journal of clinical microbiology · 2018Review
- A modified multilocus sequence typing protocol to genotype Kingella kingae from oropharyngeal swabs without bacterial isolation.BMC microbiology · 2017Article
- Article
- Investigation of Kingella kingae Invasive Infection Outbreaks in Day Care Facilities: Assessment of a Rapid Genotyping Tool Targeting the DNA Uptake Sequence.Journal of clinical microbiology · 2017Article
- Acute Septic Arthritis of the Knee Caused byFrontiers in pediatrics · 2017Article
- Kingella kingae Expresses Four Structurally Distinct Polysaccharide Capsules That Differ in Their Correlation with Invasive Disease.PLoS pathogens · 2016Article
- Polymerase chain reaction detection of Kingella kingae in children with culture-negative septic arthritis in eastern Ontario.Paediatrics & child health · 2016Article
- Penicillinase-encoding gene blaTEM-1 may be plasmid borne or chromosomally located in Kingella kingae species.Antimicrobial agents and chemotherapy · 2015Article
- Kingella kingae: carriage, transmission, and disease.Clinical microbiology reviews · 2015Review
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although Kingella kingae is the most common etiology of osteoarticular infections in young children, is a frequent cause of bacteremia in those younger than 4 years, and has been involved in clusters of invasive infections among daycare center attendees, the population structure of the species has not been systematically studied. Using multilocus sequence typing, we investigated the genetic diversity of the largest intercontinental collection of K. kingae strains to date. To facilitate typing of bacterial isolates, we developed a novel genotyping tool that targets the DNA uptake sequence (DUS). Among 324 strains isolated from asymptomatic carriers and patients from Israel, Europe, North America, and Australia with various invasive forms of the disease from 1960 to 2013, we identified 64 sequence types (STs) and 12 ST complexes (STcs). Five predominant STcs, comprising 72.2% of all strains, were distributed intercontinentally. ST-6 was the most frequent, showing a worldwide distribution, and appeared genotypically isolated by exhibiting few neighboring STs, suggesting an optimal fitness. ST-14 and ST-23 appeared to be the oldest groups of bacteria, while ST-25 probably emerged more recently from the highly evolutive ST-23. Using the DUS typing method, randomly chosen isolates were correctly classified to one of the major STcs. The comprehensive description of K. kingae evolution would help to detect new emerging clones and decipher virulence and fitness mechanisms. The rapid and reproducible DUS typing method may serve in the initial investigation of K. kingae outbreaks.
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