ArticleJournal of neurophysiology2014
Persistent beneficial impact of H-reflex conditioning in spinal cord-injured rats.
Article in Journal of neurophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03461159 (Operant Conditioning of Spinal Reflexes and Motor Evoked Potentials), which is not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Operant Conditioning of Spinal Reflexes and Motor Evoked Potentials
Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Neurorehabilitation in the 21st Century: New Science, New Strategies, New Expectations.Neurorehabilitation and neural repair · 2026Review
- Gait Analysis During Paralysis Recovery in a Rat Incomplete Spinal Cord Injury Model.JOR spine · 2025Article
- Enhancing neurorehabilitation by targeting beneficial plasticity.Frontiers in rehabilitation sciences · 2023Review
- Heksor: the central nervous system substrate of an adaptive behaviour.The Journal of physiology · 2022Article
- H-reflex conditioning during locomotion in people with spinal cord injury.The Journal of physiology · 2021Article
- Targeting Sensory and Motor Integration for Recovery of Movement After CNS Injury.Frontiers in neuroscience · 2021Review
- Repeated and patterned stimulation of cutaneous reflex pathways amplifies spinal cord excitability.Journal of neurophysiology · 2020Article
- Can Operant Conditioning of EMG-Evoked Responses Help to Target Corticospinal Plasticity for Improving Motor Function in People With Multiple Sclerosis?Frontiers in neurology · 2020Review
- Operant conditioning of the motor-evoked potential and locomotion in people with and without chronic incomplete spinal cord injury.Journal of neurophysiology · 2019Article
- The negotiated equilibrium model of spinal cord function.The Journal of physiology · 2018Review
- Retraining Reflexes: Clinical Translation of Spinal Reflex Operant Conditioning.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018Review
- Acquisition, Maintenance, and Therapeutic Use of a Simple Motor Skill.Current opinion in behavioral sciences · 2018Article
- Why New Spinal Cord Plasticity Does Not Disrupt Old Motor Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Ablation of the inferior olive prevents H-reflex down-conditioning in rats.Journal of neurophysiology · 2016Article
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Operant conditioning of a spinal cord reflex can improve locomotion in rats and humans with incomplete spinal cord injury. This study examined the persistence of its beneficial effects. In rats in which a right lateral column contusion injury had produced asymmetric locomotion, up-conditioning of the right soleus H-reflex eliminated the asymmetry while down-conditioning had no effect. After the 50-day conditioning period ended, the H-reflex was monitored for 100 [±9 (SD)] (range 79-108) more days and locomotion was then reevaluated. After conditioning ended in up-conditioned rats, the H-reflex continued to increase, and locomotion continued to improve. In down-conditioned rats, the H-reflex decrease gradually disappeared after conditioning ended, and locomotion at the end of data collection remained as impaired as it had been before and immediately after down-conditioning. The persistence (and further progression) of H-reflex increase but not H-reflex decrease in these spinal cord-injured rats is consistent with the fact that up-conditioning improved their locomotion while down-conditioning did not. That is, even after up-conditioning ended, the up-conditioned H-reflex pathway remained adaptive because it improved locomotion. The persistence and further enhancement of the locomotor improvement indicates that spinal reflex conditioning protocols might supplement current therapies and enhance neurorehabilitation. They may be especially useful when significant spinal cord regeneration becomes possible and precise methods for retraining the regenerated spinal cord are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.