Evidence map›Paper›PMID 25143458›Full record

ReviewAmerican journal of physiology. Renal physiology2014

A current understanding of vascular calcification in CKD.

Neil J Paloian, Cecilia M Giachelli

Abstract readReview
In one paragraph

Review in American journal of physiology. Renal physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 166 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
166citing papers in PubMed, 2 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

166 citing papers in PubMed, 2 syntheses or guidelines pooled it, 309 citations in OpenAlex.

  1. Pooled it
  2. Osteoporosis in Patients with Chronic Kidney Diseases: A Systemic Review.International journal of molecular sciences · 2020
    Pooled it
  3. Trial
  4. Trial
  5. Plasma levels of microRNA in chronic kidney disease: patterns in acute and chronic exercise.American journal of physiology. Heart and circulatory physiology · 2015
    Trial
  6. Article
  7. Article
  8. Article
  9. Mineralocorticoid Receptor Antagonists in Dialysis.American journal of nephrology · 2026
    Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Heliyon · 2024
    Review
  19. Article
  20. Review

106 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Neil J PaloianDivision of Nephrology, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington; and.
Cecilia M GiachelliDepartment of Bioengineering, University of Washington, Seattle, Washington ceci@uw.edu.
University of Washington · US

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
Pediatric Nephrology Training ProgramT32DK007662 · NIDDK · UNIVERSITY OF WASHINGTON · PI HINGORANI, SANGEETA · 1991 to 2020
$5.5M
Vascular Calcification MechanismR01HL062329 · NHLBI · UNIVERSITY OF WASHINGTON · PI GIACHELLI, CECILIA M · 1999 to 2017
$5.3M
Calcification and Vascular Cell DifferentiationR01HL081785 · NHLBI · UNIVERSITY OF WASHINGTON · PI GIACHELLI, CECILIA M · 2005 to 2017
$3.7M
Role of Osteoclastogenesis in Calcific Aortic Valve DiseaseR01HL114611 · NHLBI · UNIVERSITY OF WASHINGTON · PI GIACHELLI, CECILIA M · 2012 to 2016
$1.9M
NHLBI NIH HHS R01 HL062329NHLBI NIH HHS R01 HL081785NHLBI NIH HHS R01 HL114611NIDDK NIH HHS P30 DK017047NIDDK NIH HHS T32 DK007662
6 · The paper itself

Abstract

Patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) have significant cardiovascular morbidity and mortality that is in part due to the development of vascular calcification. Vascular calcification is an active, highly regulated process that shares many similarities with normal bone formation. New discoveries related to extracellular vesicles, microRNAs, and calciprotein particles continue to reveal the mechanisms that are involved in the initiation and progression of vascular calcification in CKD. Further innovations in these fields are critical for the development of biomarkers and therapeutic options for patients with CKD and ESRD.

Indexed as

CalciumDisease ProgressionElastinHumansKidney Failure, ChronicMuscle, Smooth, VascularPhosphorusRenal Insufficiency, ChronicRisk FactorsVascular CalcificationCalciumElastinPhosphoruscalciprotein particleschronic kidney diseasemicroRNAvascular calcificationvesicles

Identifiers

PMID25143458
PMCPMC4200295
OpenAlexW2162625952

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.