ArticleNature chemistry2014
A redox hydrogel protects hydrogenase from high-potential deactivation and oxygen damage.
Article in Nature chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
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Who cites it
56 citing papers in PubMed.
- A Low-Potential π‑Extended Viologen Electron Donor Results in Increased HACS organic & inorganic Au · 2026Article
- To Biotic or Abiotic: Biohybrid Systems for Artificial Photosynthesis.Chemical reviews · 2026Review
- Electroenzymatic COAngewandte Chemie (International ed. in English) · 2026Review
- Organic Materials for Biohybrid Photocatalysis and Photoelectrochemical Devices.Chemical reviews · 2026Review
- Electrochemical Protection of Cyanobacterial Cells from Molecular Oxygen Enables Sustained PhotoHAngewandte Chemie (International ed. in English) · 2026Article
- Surface Immobilization of Metalloenzymes Usinga Pyrene-Modified Hydrogel.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Cobaltocene Polymers for Low-Potential Enzymatic Electrocatalysis.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Turning the FeFe hydrogenase fromProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Bioelectrochemical Systems: Prioritizing Energy Density, Long-Term Stability, and Validation.ACS energy letters · 2025Review
- Connecting Biological and Synthetic Approaches for Electrocatalytic COAngewandte Chemie (International ed. in English) · 2024Review
- Developing high-affinity, oxygen-insensitive [NiFe]-hydrogenases as biocatalysts for energy conversion.Biochemical Society transactions · 2023Review
- Structure and function relationship of formate dehydrogenases: an overview of recent progress.IUCrJ · 2023Review
- Recent advances in enzymatic biofuel cells enabled by innovative materials and techniques.Exploration (Beijing, China) · 2023Review
- From Protein Film Electrochemistry to Nanoconfined Enzyme Cascades and the Electrochemical Leaf.Chemical reviews · 2023Review
- In Situ Confocal Raman Microscopy of Redox Polymer Films on Bulk Electrode Supports.ACS measurement science au · 2023Article
- Enzymatic and Microbial Electrochemistry: Approaches and Methods.ACS measurement science au · 2022Review
- Polymer Dots as Photoactive Membrane Vesicles for [FeFe]-Hydrogenase Self-Assembly and Solar-Driven Hydrogen Evolution.Journal of the American Chemical Society · 2022Article
- Second and Outer Coordination Sphere Effects in Nitrogenase, Hydrogenase, Formate Dehydrogenase, and CO Dehydrogenase.Chemical reviews · 2022Review
- Visualizing the gas channel of a monofunctional carbon monoxide dehydrogenase.Journal of inorganic biochemistry · 2022Article
- Stability of the H-cluster under whole-cell conditions-formation of an HJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydrogenases are nature's efficient catalysts for both the generation of energy via oxidation of molecular hydrogen and the production of hydrogen via the reduction of protons. However, their O2 sensitivity and deactivation at high potential limit their applications in practical devices, such as fuel cells. Here, we show that the integration of an O2-sensitive hydrogenase into a specifically designed viologen-based redox polymer protects the enzyme from O2 damage and high-potential deactivation. Electron transfer between the polymer-bound viologen moieties controls the potential applied to the active site of the hydrogenase and thus insulates the enzyme from excessive oxidative stress. Under catalytic turnover, electrons provided from the hydrogen oxidation reaction induce viologen-catalysed O2 reduction at the polymer surface, thus providing self-activated protection from O2. The advantages of this tandem protection are demonstrated using a single-compartment biofuel cell based on an O2-sensitive hydrogenase and H2/O2 mixed feed under anode-limiting conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.