Evidence map›Paper›PMID 25143120›Full record

ArticleCurrent treatment options in cardiovascular medicine2014

Childhood obesity and autonomic dysfunction: risk for cardiac morbidity and mortality.

Duanping Liao, Sol M Rodríguez-Colón, Fan He, Edward O Bixler

Open access · greenAbstract read
In one paragraph

Article in Current treatment options in cardiovascular medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 28 citations in OpenAlex.

  1. Effect of high-intensity childhood games on heart rate variability, saliva leptin concentrations, and body composition in children.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025
    Trial
  2. Predictors of Cardiac Autonomic Dysfunction in Obesity-Related Hypertension.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2024
    Article
  3. Analysis of heart rate as a predictor of changes in heart rate variability in children.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Duanping LiaoDepartment of Public Health Sciences, Penn State University College of Medicine, 90 Hope Drive, Suite 2000/A210, PO Box 855, Hershey, PA, 17033, USA, dliao@phs.psu.edu.
Sol M Rodríguez-Colón
Fan He
Edward O Bixler
Pennsylvania State University · USPenn State Milton S. Hershey Medical Center · US

Funding

Penn State Clinical and Translational Science InstituteUL1TR000127 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SINOWAY, LAWRENCE I · 2012 to 2015
$17.1M
Sleep and cardio-metabolic risk factors: a prospective study of adolescentsR01HL097165 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI BIXLER, EDWARD O., LIAO, DUANPING · 2010 to 2013
$2.2M
PREVALENCE OF SLEEP DISORDERED BREATHING IN CHILDRENR01HL063772 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI BIXLER, EDWARD O. · 2001 to 2005
$1.3M
Sleep-disordered breathing, sleep stages, and heart rate variability in childrenR21HL087858 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LIAO, DUANPING · 2007 to 2008
$403k
NCATS NIH HHS UL1 TR000127NHLBI NIH HHS R01 HL063772NHLBI NIH HHS R01 HL097165NHLBI NIH HHS R21 HL087858
6 · The paper itself

Abstract

opinion statementThe epidemic of childhood obesity is becoming a major predictor for risk of cardiovascular diseases (CVD) and mortality during adulthood. Alterations in the morphology of the heart due to obesity could be a predictor for the dysfunction of cardiac autonomic modulation (CAM). A number of epidemiologic studies have evaluated the effect of obesity and CAM in children, finding that obesity impaired the balance of CAM toward a sympathetic overflow and reduced parasympathetic modulation, a significant predictor of CVD morbidity and mortality in adults. Lifestyle modifications, for example long-term exercise programs, have been shown to improve CAM in the obese. This review discusses the recent evidence on childhood and adolescent obesity and its impact on CAM, as well as how early lifestyle changes could help improve CAM, which may in turn reduce the burden of CVD in adults.

Identifiers

PMID25143120
PMCPMC4159679
OpenAlexW2014669673

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.