ArticleEuropean journal of nuclear medicine and molecular imaging2014
Quantitation of myocardial blood flow and myocardial flow reserve with 99mTc-sestamibi dynamic SPECT/CT to enhance detection of coronary artery disease.
Article in European journal of nuclear medicine and molecular imaging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 80 citations in OpenAlex.
- Quantitative and semi-quantitative comparison of myocardial blood flow betweenQuantitative imaging in medicine and surgery · 2026Article
- Feasibility of Quantitative Myocardial Perfusion with CZT SPECT and SPECT/CT: Current Limitations and Recommendations for Future Improvements.Current cardiology reports · 2026Review
- FedDA-TSformer: Federated Domain Adaptation with vision TimeSformer for left ventricle segmentation on gated myocardial perfusion SPECT image.BMC methods · 2026Article
- Comparison of global and regional myocardial blood flow quantification using dynamic solid-state detector SPECT and Tc-99 m-sestamibi or Tc-99 m-tetrofosmin in a routine clinical setting.The international journal of cardiovascular imaging · 2025Article
- Deep learned triple-tracer multiplexed PET myocardial image separation.Frontiers in nuclear medicine · 2024Article
- SPECT measurements of myocardial blood flow and flow reserve: from development to implementation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Prognostic value of myocardial flow reserve derived by quantitative SPECT for patients with intermediate coronary stenoses.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Diagnostic value of quantitative myocardial blood flow assessment by NaI(Tl) SPECT in detecting significant stenosis: a prospective, multi-center study.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- The diagnostic value of SPECT CZT quantitative myocardial blood flow in high-risk patients.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Myocardial blood flow quantitation with the SPECT technique: Where do we stand?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- SPECT-derived absolute myocardial perfusion measures: A step in the right direction.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Quantification of myocardial blood flow by CZT-SPECT with motion correction and comparison withJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- The Evaluation of Left Ventricle Ischemic Extent in Patients with Significantly Suspicious Cardiovascular Disease byDiagnostics (Basel, Switzerland) · 2021Article
- The Importance of Time-of-Flight Reconstruction and Point Spread Modeling in the Measurement of Myocardial Blood Flow Parameters.Current cardiology reports · 2021Review
- Clinical Application of Dynamic SPECT/CT in a Patient with Prior Myocardial Infarction Underwent Percutaneous Coronary Intervention Twice.Diagnostics (Basel, Switzerland) · 2021Article
- Assessment of cardiac amyloidosis withEJNMMI physics · 2021Article
- Myocardial blood flow quantitation in patients with congestive heart failure: head-to-head comparison between rapid-rotating gantry SPECT and CZT SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- SPECT quantification of myocardial blood flow: A journey of a thousand miles begins with a single step (Lao Tzu, Chinese philosopher, 604-531 BC).Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- The tools are ready, are we?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Advances in imaging instrumentation for nuclear cardiology.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Review
Corrections and comments
- Commented on by
Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeConventional dual-head single photon emission computed tomography (SPECT)/CT systems capable of fast dynamic SPECT (DySPECT) imaging have a potential for flow quantitation. This study introduced a new method to quantify myocardial blood flow (MBF) and myocardial flow reserve (MFR) with DySPECT scan and evaluated the diagnostic performance of detecting coronary artery disease (CAD) compared with perfusion using invasive coronary angiography (CAG) as the reference standard.
methodsThis study included 21 patients with suspected or known CAD who had received DySPECT, ECG-gated SPECT (GSPECT), and CAG (13 with ≥ 50% stenosis in any vessel; non-CAD group: 8 with patent arteries or < 50% stenosis). DySPECT and GSPECT scans were performed on a widely used dual-head SPECT/CT scanner. The DySPECT imaging protocol utilized 12-min multiple back-and-forth gantry rotations during injections of (99m)Tc-sestamibi (MIBI) tracer at rest or dipyridamole-stress stages. DySPECT images were reconstructed with full physical corrections and converted to the physical unit of becquerels per milliliter. Stress MBF (SMBF), rest MBF (RMBF), and MFR were quantified by a one-tissue compartment flow model using time-activity curves derived from DySPECT images. Perfusion images were processed for GSPECT scan and interpreted to obtain summed stress score (SSS) and summed difference score (SDS). Receiver-operating characteristic (ROC) analyses were conducted to evaluate the diagnostic performance of flow and perfusion.
resultsUsing the criteria of ≥ 50% stenosis as positive CAD, areas under the ROC curve (AUCs) of flow assessment were overall significantly greater than those of perfusion. For patient-based analysis, AUCs for MFR, SMBF, SSS, and SDS were 0.91 ± 0.07, 0.86 ± 0.09, 0.64 ± 0.12, and 0.59 ± 0.13. For vessel-based analysis, AUCs for MFR, SMBF, SSS, and SDS were 0.81 ± 0.05, 0.76 ± 0.06, 0.62 ± 0.07, and 0.56 ± 0.08, respectively.
conclusionThe preliminary data suggest that MBF quantitation with a conventional SPECT/CT system and the flow quantitation method is a clinically effective approach to enhance CAD detection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.