ArticleNephrology (Carlton, Vic.)2014
Proton-pump inhibitor use is associated with lower urinary magnesium excretion.
Article in Nephrology (Carlton, Vic.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Pooled it
- Proton pump inhibitors use is associated with a higher prevalence of kidney stones: NHANES 2007-2018.BMC public health · 2024Article
- An exploratory study evaluated the 30 most commonly reported medications in the United States food and drug administration's adverse event reporting system that are associated with the occurrence of kidney stones.Frontiers in pharmacology · 2024Article
- Influence of Isoflavones and Probiotics on Magnesium Status in Healthy Female Rats.Foods (Basel, Switzerland) · 2023Article
- Proton pump inhibitors use and risk of incident nephrolithiasis.Urolithiasis · 2022Article
- Mechanisms of proton pump inhibitor-induced hypomagnesemia.Acta physiologica (Oxford, England) · 2022Review
- Proton-pump inhibitors associated with decreased urinary citrate excretion.International urology and nephrology · 2021Article
- Use of Proton Pump Inhibitors Increases Risk of Incident Kidney Stones.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2021Article
- The association between use of proton-pump inhibitors and excess mortality after kidney transplantation: A cohort study.PLoS medicine · 2020Observational
- Electrolyte disturbances in children receiving omeprazole for gastroesophageal reflux disease.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2020Article
- Proton-Pump Inhibitors and Hypomagnesaemia in Kidney Transplant Recipients.Journal of clinical medicine · 2019Article
- Proton pump inhibitors and adverse effects in kidney transplant recipients: A meta-analysis.World journal of transplantation · 2019Article
- The role of magnesium sulfate in the intensive care unit.EXCLI journal · 2017Review
- Proton Pump Inhibitors Are Not Associated With Acute Kidney Injury in Critical Illness.Journal of clinical pharmacology · 2016Article
- Proton-pump inhibitor-induced hypomagnesemia: Current research and proposed mechanisms.World journal of nephrology · 2016Review
- The relationship between proton pump inhibitor use and serum magnesium concentration among hemodialysis patients: a cross-sectional study.BMC nephrology · 2015Article
- Proton pump inhibitor use is not associated with cardiac arrhythmia in critically ill patients.Journal of clinical pharmacology · 2015Article
- Proton Pump Inhibitor Use and Magnesium Concentrations in Hemodialysis Patients: A Cross-Sectional Study.PloS one · 2015Article
- Hypomagnesemia Induced by Long-Term Treatment with Proton-Pump Inhibitors.Gastroenterology research and practice · 2015Review
- The Effect of Omeprazole on Urinary Magnesium Excretion in Children with Peptic Diseases.Journal of research in pharmacy practiceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
aimsAlthough multiple recent studies have confirmed an association between chronic proton-pump inhibitor (PPI) use and hypomagnesaemia, the physiologic explanation for this association remains uncertain. To address this, we investigated the association of PPI use with urinary magnesium excretion.
methodsWe measured 24-hour urine magnesium excretion in collections performed for nephrolithiasis evaluation in 278 consecutive ambulatory patients and determined PPI use from contemporaneous medical records.
resultsThere were 50 (18%) PPI users at the time of urine collection. The mean daily urinary magnesium was 84.6 ± 42.8 mg in PPI users, compared with 101.2 ± 41.1 mg in non-PPI users (P = 0.01). In adjusted analyses, PPI use was associated with 10.54 ± 5.30 mg/day lower daily urinary magnesium excretion (P = 0.05). Diuretic use did not significantly modify the effect of PPI on urinary magnesium. As a control, PPI use was not associated with other urinary indicators of nutritional intake.
conclusionsOur findings suggest that PPI use is associated with lower 24-hour urine magnesium excretion. Whether this reflects decreased intestinal uptake due to PPI exposure, or residual confounding due to decreased magnesium intake, requires further study.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.