ArticleEndocrine2015
Adipokines and biochemical changes in Egyptian obese subjects: possible variation with sex and degree of obesity.
Article in Endocrine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- An Exploratory Critical Review on TNF-α as a Potential Inflammatory Biomarker Responsive to Dietary Intervention with Bioactive Foods and Derived Products.Foods (Basel, Switzerland) · 2022Review
- CTRP9 overexpression attenuates palmitic acid-induced inflammation, apoptosis and impaired migration in HTR8/SVneo cells through AMPK/SREBP1c signaling.Experimental and therapeutic medicine · 2022Article
- Different Changes in Adipokines, Lipid Profile, and TNF-Alpha Levels between 10 and 20 Whole Body Cryostimulation Sessions in Individuals with I and II Degrees of Obesity.Biomedicines · 2022Article
- Circulating IL-6, clusterin and irisin in obese subjects with different grades of obesity: association with insulin resistance and sexual dimorphism.Archives of endocrinology and metabolism · 2021Article
- Effect of Acupoint Embedding on Serum Leptin and Hypothalamus Leptin Receptor Expression in Rats with Simple Obesity.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Review
- Mechanisms Linking Inflammation to Insulin Resistance.International journal of endocrinology · 2015Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was firstly to evaluate the adipokines and biochemical changes in obese subjects in relation to different grades of obesity and in relation to gender difference (males versus females) and secondly to evaluate the role of TNF-α in obesity. From January 2013 to February 2014, a total number of 120 non-diabetic subjects of both sexes were recruited and randomly selected from Dr. Abd-Elhamid Elsheikh center for physiotherapy and weight control, El-menofia-Egypt. Those subjects were classified according to their sex into two main groups; the female group and the male group. The female group (60 women) was distributed according to BMI into group 1 (15 lean women), group 2 (15 class I obese women), group 3 (15 class II obese women), and group 4 (15 class III obese women). The male group (60 men) was also distributed according to the BMI into group 1 (15 lean men), group 2 (15 class I obese men), group 3 (15 class II obese men), and group 4 (15 class III obese men). All individuals enrolled in the study were submitted to weight and height measurements with subsequent calculation of body mass index. Fasting blood samples were collected from all participants for quantitative determination of blood glucose, serum lipid, TNF-α, leptin, and adiponectin levels. One-way analysis of variance followed by LSD post hoc test was used for comparison of variables. In obese subjects of both sexes, it was found that circulating leptin and TNF-α levels were significantly high (P<0.05) and positively correlated to BMI. In contrast to leptin, adiponectin concentrations were significantly low (P<0.05) and inversely correlated to BMI. Regarding gender difference, although serum leptin and adiponectin levels were higher in women than men, men showed higher atherogenic parameters. We conclude that leptin, TNF-α, and adiponectin were related to both BMI and grades of obesity. Furthermore, TNF-α may play a role in obesity.
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Registered trials
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