ArticleJournal of gynecologic oncology2014
Lymphadenectomy can be omitted for low-risk endometrial cancer based on preoperative assessments.
Article in Journal of gynecologic oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 47 citations in OpenAlex.
- A nomogram model based on dual-center data predicts lymph node metastasis in endometrial cancer.Discover oncology · 2026Article
- Impact of Para-Aortic Lymphadenectomy on Clinically FIGO Stage IIIC1 High-Grade Endometrial Cancer: A Retrospective Cohort Study from Two Tertiary Centers in Korea and Taiwan.Medicina (Kaunas, Lithuania) · 2025Article
- Incorporation of Tumor-Free Distance and Other Alternative Ultrasound Biomarkers into a Myometrial Invasion-Based Model Better Predicts Lymph Node Metastasis in Endometrial Cancer: Evidence and Future Prospects.Diagnostics (Basel, Switzerland) · 2022Article
- Review
- The prognosis of endometrial cancers stratified with conventional risk factors and modified molecular classification.Cancer science · 2022Article
- Quantitative Measurement of Progesterone Receptor Immunohistochemical Expression to Predict Lymph Node Metastasis in Endometrial Cancer.Diagnostics (Basel, Switzerland) · 2022Article
- Ultrasound Measurement of Tumor-Free Distance from the Serosal Surface as the Alternative to Measuring the Depth of Myometrial Invasion in Predicting Lymph Node Metastases in Endometrial Cancer.Diagnostics (Basel, Switzerland) · 2021Article
- Lymphadenectomy issues in endometrial cancer.Journal of gynecologic oncology · 2021Review
- Using Deep Learning with Convolutional Neural Network Approach to Identify the Invasion Depth of Endometrial Cancer in Myometrium Using MR Images: A Pilot Study.International journal of environmental research and public health · 2020Article
- Effect of Pelvic Lymphadenectomy on Survival in Patients with Low-Risk Early-Stage Endometrial Cancer Diagnosed Intraoperatively Using Frozen Tissue Sections: A Retrospective Analysis.Cancer management and research · 2020Article
- A Prediction Model for Preoperative Risk Assessment in Endometrial Cancer Utilizing Clinical and Molecular Variables.International journal of molecular sciences · 2019Article
- Contributions of the Japanese Gynecologic Oncology Group (JGOG) in Improving the Quality of Life in Women With Gynecological Malignancies.Current oncology reports · 2017Review
- A novel model to estimate lymph node metastasis in endometrial cancer patients.Clinics (Sao Paulo, Brazil) · 2017Article
- Overexpression of microRNA-205 predicts lymph node metastasis and indicates an unfavorable prognosis in endometrial cancer.Oncology letters · 2016Article
- Long-term outcomes of magnetic resonance imaging-invisible endometrial cancer.Journal of gynecologic oncology · 2016Article
- Stratification of endometrioid endometrial cancer patients into risk levels using somatic mutations.Gynecologic oncology · 2016Article
- Feasibility of a reduced field-of-view diffusion-weighted (rFOV) sequence in assessment of myometrial invasion in patients with clinical FIGO stage I endometrial cancer.Journal of magnetic resonance imaging : JMRI · 2016Article
- Article
- A critical assessment on the role of sentinel node mapping in endometrial cancer.Journal of gynecologic oncology · 2015Article
- Asian Society of Gynecologic Oncology International Workshop 2014.Journal of gynecologic oncology · 2015Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAccording to the International Federation of Gynecology and Obstetrics staging, some surgeons perform lymphadenectomy in all patients with early stage endometrial cancer to enable the accurate staging. However, there are some risks to lymphadenectomy such as lower limb lymphedema. The aim of this study was to investigate whether preoperative assessment is useful to select the patients in whom lymphadenectomy can be safely omitted.
methodsWe evaluated the risk of lymph node metastasis (LNM) using LNM score (histological grade, tumor volume measured in magnetic resonance imaging [MRI], and serum CA-125), myometrial invasion and extrautrerine spread assessed by MRI. Fifty-six patients of which LNM score was 0 and myometrial invasion was less than 50% were consecutively enrolled in the study in which a lymphadenectomy was initially intended not to perform. We analyzed several histological findings and investigated the recurrence rate and overall survival.
resultsFifty-one patients underwent surgery without lymphadenectomy. Five (8.9%) who had obvious myometrial invasion intraoperatively underwent systematic lymphadenectomy. One (1.8%) with endometrial cancer which was considered to arise from adenomyosis had para-aortic LNM. Negative predictive value of deep myometrial invasion was 96.4% (54/56). During the mean follow-up period of 55 months, one patient with deep myometrial invasion who refused an adjuvant therapy had tumor recurrence. The overall survival rate was 100% during the study period.
conclusionThis preoperative assessment is useful to select the early stage endometrial cancer patients without risk of LNM and to safely omit lymphadenectomy.
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