ArticleMovement disorders : official journal of the Movement Disorder Society2014
Onset of Huntington's disease: can it be purely cognitive?
Article in Movement disorders : official journal of the Movement Disorder Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 62 citations in OpenAlex.
- Do cognitive tests capture symptoms that matter to people with Huntington's disease?Scientific reports · 2025Article
- Progression of visual cognition and neuropsychiatric symptoms in Huntington's disease: a 1-year follow-up study across preclinical and clinical phases.Frontiers in psychology · 2025Article
- Frontotemporal dementia phenotype in late-onset Huntington disease without chorea.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Functional topologies of spatial cognition predict cognitive and motor progression in Parkinson's.Frontiers in aging neuroscience · 2022Article
- Validation Study of a German Cognitive Battery for Huntington's Disease: Relationship Between Cognitive Performance, Functional Decline, and Disease Burden.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2021Article
- Time will tell: Decision making in premanifest and manifest Huntington's disease.Brain and behavior · 2020Article
- Biological and clinical characteristics of gene carriers far from predicted onset in the Huntington's disease Young Adult Study (HD-YAS): a cross-sectional analysis.The Lancet. Neurology · 2020Article
- Development and Evaluation of Maze-Like Puzzle Games to Assess Cognitive and Motor Function in Aging and Neurodegenerative Diseases.Frontiers in aging neuroscience · 2020Article
- The effect of impulsivity and inhibitory control deficits in the saccadic behavior of premanifest Huntington's disease individuals.Orphanet journal of rare diseases · 2019Article
- Mutant Huntingtin Causes a Selective Decrease in the Expression of Synaptic Vesicle Protein 2C.Neuroscience bulletin · 2018Article
- Age at Death and Causes of Death in Patients with Huntington Disease in Norway in 1986-2015.Journal of Huntington's disease · 2018Article
- Resting-state functional MRI reveals altered brain connectivity and its correlation with motor dysfunction in a mouse model of Huntington's disease.Scientific reports · 2017Article
- A selective inhibitor of histone deacetylase 3 prevents cognitive deficits and suppresses striatal CAG repeat expansions in Huntington's disease mice.Scientific reports · 2017Article
- Modulating Neurotrophin Receptor Signaling as a Therapeutic Strategy for Huntington's Disease.Journal of Huntington's disease · 2017Review
- ROBUST MIXED EFFECTS MODEL FOR CLUSTERED FAILURE TIME DATA: APPLICATION TO HUNTINGTON'S DISEASE EVENT MEASURES.The annals of applied statistics · 2017Article
- Review
- Phenotype Characterization of HD Intermediate Alleles in PREDICT-HD.Journal of Huntington's disease · 2016Article
- Longitudinal Psychiatric Symptoms in Prodromal Huntington's Disease: A Decade of Data.The American journal of psychiatry · 2016Article
- Cholesterol-loaded nanoparticles ameliorate synaptic and cognitive function in Huntington's disease mice.EMBO molecular medicine · 2015Article
- Multivariate prediction of motor diagnosis in Huntington's disease: 12 years of PREDICT-HD.Movement disorders : official journal of the Movement Disorder Society · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Knowledge of the cognitive manifestation of Huntington's disease has burgeoned over the past two decades. Many studies from independent datasets have shown that cognitive impairment is evident before motor diagnosis, and annual cognitive decline is a robust marker of disease progression. Additionally, cognition is a critical concern to patients and families and is associated with meaningful outcomes, including functional capacity, driving, loss of accustomed work, and quality of life. In the past few years, Huntington's disease animal models of cognition have increased, preparing for preclinical experimental therapeutics with cognitive endpoints. A longitudinal analysis of cognitive variables was conducted with 559 gene-positive cases and 233 controls showing no signs of motor abnormalities over approximately a 3-year period. Results show statistically significant differences in rate of annual change for some cognitive variables, such that the cases group had worsening performance over time. These findings show that cognitive deterioration can be seen in persons with the Huntington's disease gene expansion with no overt motor signs or symptoms, suggesting that cognitive onset of Huntington's disease may precede motor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.