ArticleSleep2014
Genetic rescue of functional senescence in synaptic and behavioral plasticity.
Article in Sleep, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
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- Mild sleep restriction increases endothelial oxidative stress in female persons.Scientific reports · 2023Article
- Sleep deprivation, sleep fragmentation, and social jet lag increase temperature preference inFrontiers in neuroscience · 2023Article
- A brain-wide form of presynaptic active zone plasticity orchestrates resilience to brain aging in Drosophila.PLoS biology · 2022Article
- Manipulations of the olfactory circuit highlight the role of sensory stimulation in regulating sleep amount.Sleep · 2021Article
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- Epigenetic regulator Stuxnet modulates octopamine effect on sleep through a Stuxnet-Polycomb-Octβ2R cascade.EMBO reports · 2021Article
- Rest Is Required to Learn an Appetitively-Reinforced Operant Task inFrontiers in behavioral neuroscience · 2021Article
- Aging and the clock: Perspective from flies to humans.The European journal of neuroscience · 2020Review
- Sleep-wake-driven and circadian contributions to daily rhythms in gene expression and chromatin accessibility in the murine cortex.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Short-Term Memory Deficits in the SLEEP Inbred Panel.Clocks & sleep · 2019Article
- The clock gene period differentially regulates sleep and memory in Drosophila.Neurobiology of learning and memory · 2018Article
- Presynaptic Aβ40 prevents synapse addition in the adult Drosophila neuromuscular junction.PloS one · 2017Article
- Enhanced sleep reverses memory deficits and underlying pathology in Drosophila models of Alzheimer's disease.Neurobiology of sleep and circadian rhythms · 2017Article
- Acetylcholine from Visual Circuits Modulates the Activity of Arousal Neurons in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Sleep, Performance, and Memory in Flies.Current sleep medicine reports · 2015Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
STUDY
objectivesAging has been linked with decreased neural plasticity and memory formation in humans and in laboratory model species such as the fruit fly, Drosophila melanogaster. Here, we examine plastic responses following social experience in Drosophila as a high-throughput method to identify interventions that prevent these impairments. PATIENTS OR
participantsWild-type and transgenic Drosophila melanogaster. DESIGN AND
interventionsYoung (5-day old) or aged (20-day old) adult female Drosophila were housed in socially enriched (n = 35-40) or isolated environments, then assayed for changes in sleep and for structural markers of synaptic terminal growth in the ventral lateral neurons (LNVs) of the circadian clock. MEASUREMENTS AND
resultsWhen young flies are housed in a socially enriched environment, they exhibit synaptic elaboration within a component of the circadian circuitry, the LNVs, which is followed by increased sleep. Aged flies, however, no longer exhibit either of these plastic changes. Because of the tight correlation between neural plasticity and ensuing increases in sleep, we use sleep after enrichment as a high-throughput marker for neural plasticity to identify interventions that prolong youthful plasticity in aged flies. To validate this strategy, we find three independent genetic manipulations that delay age-related losses in plasticity: (1) elevation of dopaminergic signaling, (2) over-expression of the transcription factor blistered (bs) in the LNVs, and (3) reduction of the Imd immune signaling pathway. These findings provide proof-of-principle evidence that measuring changes in sleep in flies after social enrichment may provide a highly scalable assay for the study of age-related deficits in synaptic plasticity.
conclusionsThese studies demonstrate that Drosophila provides a promising model for the study of age-related loss of neural plasticity and begin to identify genes that might be manipulated to delay the onset of functional senescence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.