ArticleSleep2014
Sleep deprivation aggravates median nerve injury-induced neuropathic pain and enhances microglial activation by suppressing melatonin secretion.
Article in Sleep, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 74 citations in OpenAlex.
- rTMS targeted to the secondary somatosensory cortex influences sleep in CRPS patients, as measured with the OURA ring.Brain and behavior · 2023Trial
- Adjuvant use of melatonin for relieving symptoms of painful diabetic neuropathy: results of a randomized, double-blinded, controlled trial.European journal of clinical pharmacology · 2021Trial
- Chronic Sleep Disturbance Enhances Inflammation and Collagen Production in Neural- and Myofascial Tissues in Uninjured Rats.International journal of molecular sciences · 2026Article
- The effects of sleep disturbances on patients receiving methadone treatment for opioid use disorder: cortical thickness evidence.Frontiers in psychiatry · 2026Article
- Review
- At the Intersection of Pain and Sleep: a Roadmap for Preclinical Pain Research.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- Modulating the Pronociceptive Effect of Sleep Deprivation: A Possible Role for Cholinergic Neurons in the Medial Habenula.Neuroscience bulletin · 2024Article
- Postoperative cognitive dysfunction: spotlight on light, circadian rhythms, and sleep.Frontiers in neuroscience · 2024Review
- Sleep as a Therapeutic Target for Pain Management.Current pain and headache reports · 2023Review
- Stress Induces Prolonged Pain Recovery After Surgery: Involvement of Glucocorticoid-Related Pathway.The international journal of neuropsychopharmacology · 2023Article
- People's experiences living with peripheral neuropathy: a qualitative study.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- Sleep disorders in chronic pain and its neurochemical mechanisms: a narrative review.Frontiers in psychiatry · 2023Review
- Gut Bless Your Pain-Roles of the Gut Microbiota, Sleep, and Melatonin in Chronic Orofacial Pain and Depression.Biomedicines · 2022Review
- Sleep Loss Causes Dysfunction in Murine Extraorbital Lacrimal Glands.Investigative ophthalmology & visual science · 2022Article
- Associations of sleep problems with asthma and allergic rhinitis among Chinese preschoolers.Scientific reports · 2022Article
- The vicious interplay between disrupted sleep and malignant brain tumors: a narrative review.Croatian medical journal · 2021Review
- Melatonin Moderates the Triangle of Chronic Pain, Sleep Architecture and Immunometabolic Traffic.Biomedicines · 2021Review
- Melatonin and Microglia.International journal of molecular sciences · 2021Review
- Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice.Nature communications · 2021Article
- The Role of Perioperative Sleep Disturbance in Postoperative Neurocognitive Disorders.Nature and science of sleep · 2021Review
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesSleep deprivation is common in patients with neuropathic pain, but the effect of sleep deprivation on pathological pain remains uncertain. This study investigated whether sleep deprivation aggravates neuropathic symptoms and enhances microglial activation in the cuneate nucleus (CN) in a median nerve chronic constriction injury (CCI) model. Also, we assessed if melatonin supplements during the sleep deprived period attenuates these effects.
designRats were subjected to sleep deprivation for 3 days by the disc-on-water method either before or after CCI. In the melatonin treatment group, CCI rats received melatonin supplements at doses of 37.5, 75, 150, or 300 mg/kg during sleep deprivation. Melatonin was administered at 23:00 once a day.
participantsMale Sprague-Dawley rats, weighing 180-250 g (n = 190), were used. MEASUREMENTS: Seven days after CCI, behavioral testing was conducted, and immunohistochemistry, immunoblotting, and enzyme-linked immunosorbent assay were used for qualitative and quantitative analyses of microglial activation and measurements of proinflammatory cytokines.
resultsIn rats who underwent post-CCI sleep deprivation, microglia were more profoundly activated and neuropathic pain was worse than those receiving pre-CCI sleep deprivation. During the sleep deprived period, serum melatonin levels were low over the 24-h period. Administration of melatonin to CCI rats with sleep deprivation significantly attenuated activation of microglia and development of neuropathic pain, and markedly decreased concentrations of proinflammatory cytokines.
conclusionsSleep deprivation makes rats more vulnerable to nerve injury-induced neuropathic pain, probably because of associated lower melatonin levels. Melatonin supplements to restore a circadian variation in melatonin concentrations during the sleep deprived period could alleviate nerve injury-induced behavioral hypersensitivity.
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