Evidence map›Paper›PMID 25142571›Full record

Trial reportSleep2014

Cognitive behavioral therapy vs. Tai Chi for late life insomnia and inflammatory risk: a randomized controlled comparative efficacy trial.

Michael R Irwin, Richard Olmstead, Carmen Carrillo, Nina Sadeghi, Elizabeth C Breen, Tuff Witarama, Megumi Yokomizo, Helen Lavretsky, Judith E Carroll, Sarosh J Motivala and 2 more

Registry-linked trialOpen access · bronzeAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Sleep, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02460666 (Brain Connectivity and Response to Tai Chi in Geriatric Depression), which is not on this map. Cited by 147 papers, 29 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
147citing papers in PubMed, 29 pooled it
19.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02460666 nacompletednot on this mapstarted 2016, after this paper: background citation

Brain Connectivity and Response to Tai Chi in Geriatric Depression

TypeinterventionalSponsorUniversity of California, Los AngelesRan2016 to 2020Enrolled220ConditionsMajor Depressive DisorderArmsTai-Chi-Chih (TCC), Health Education and Wellness Classes (HEW)
3 · Its place in the literature

Who cites it

147 citing papers in PubMed, 29 syntheses or guidelines pooled it, 292 citations in OpenAlex.

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87 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Michael R Irwin
Richard Olmstead
Carmen Carrillo
Nina Sadeghi
Elizabeth C Breen
Tuff Witarama
Megumi Yokomizo
Helen Lavretsky
Judith E Carroll
Sarosh J Motivala
Richard Bootzin
Perry Nicassio
University of California, Los Angeles · USUniversity of Arizona · US

Funding

UCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MOORE, ALISON AHERN · 2006 to 2017
$9.8M
NIA NIH HHS P30 AG028748
6 · The paper itself

Abstract

STUDY

objectivesTo investigate the comparative efficacy of cognitive behavioral therapy (CBT), Tai Chi Chih (TCC), and sleep seminar education control (SS) on the primary outcome of insomnia diagnosis, and secondary outcomes of sleep quality, fatigue, depressive symptoms, and inflammation in older adults with insomnia.

designRandomized controlled, comparative efficacy trial.

settingLos Angeles community. PATIENTS: 123 older adults with chronic and primary insomnia.

interventionsRandom assignment to CBT, TCC, or SS for 2-hour group sessions weekly over 4 months with follow-up at 7 and 16 months. MEASUREMENTS: Insomnia diagnosis, patient-reported outcomes, polysomnography (PSG), and high-sensitivity C-reactive protein (CRP) levels.

resultsCBT performed better than TCC and SS in remission of clinical insomnia as ascertained by a clinician (P < 0.01), and also showed greater and more sustained improvement in sleep quality, sleep parameters, fatigue, and depressive symptoms than TCC and SS (all P values < 0.01). As compared to SS, CBT was associated with a reduced risk of high CRP levels (> 3.0 mg/L) at 16 months (odds ratio [OR], 0.26 [95% CI, 0.07-0.97] P < 0.05). Remission of insomnia was associated with lower levels of CRP (P < 0.05) at 16 months. TCC was associated with improvements in sleep quality, fatigue, and depressive symptoms as compared to SS (all P's < 0.05), but not insomnia remission. PSG measures did not change.

conclusionsTreatment of late-life insomnia is better achieved and sustained by cognitive behavioral therapies. Insomnia treatment and remission reduces a marker of inflammatory risk, which has implications for cardiovascular morbidity and diabetes observed with sleep disturbance in epidemiologic surveys.

Indexed as

Cognitive Behavioral TherapyTai JiAgedAged, 80 and overC-Reactive ProteinDepressionFatigueFemaleHumansInflammationLos AngelesMaleMiddle AgedPatient Education as TopicPolysomnographyRiskC-Reactive Proteinbehavioral treatmentinflammationinsomnialate liferandomized controlled trial

Identifiers

PMID25142571
PMCPMC4153053
OpenAlexW1973787487

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.