ArticleSleep2014
Characterization of sleep in Aplysia californica.
Article in Sleep, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Invertebrate brains as diversified models for understanding sleep mechanisms and function.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
- Age-related degradation of behavioral and network features ofFrontiers in aging neuroscience · 2026Article
- Can sleep be "banked"? A PRO-CON debate.Sleep · 2025Article
- Harnessing Simple Animal Models to Decode Sleep Mysteries.Molecular biotechnology · 2025Review
- Age-related degradation of behavioral and network features ofbioRxiv : the preprint server for biology · 2025Article
- Tapeworm infection affects sleep-like behavior in three-spined sticklebacks.Scientific reports · 2024Article
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- A perspective on neuroethology: what the past teaches us about the future of neuroethology.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Review
- The 2020 Pittendrigh/Aschoff Lecture: My Circadian Journey.Journal of biological rhythms · 2021Article
- The Sleep Nullifying Apparatus: A Highly Efficient Method of Sleep Depriving Drosophila.Journal of visualized experiments : JoVE · 2020Article
- What Is REM Sleep?Current biology : CB · 2020Review
- Tired and stressed: Examining the need for sleep.The European journal of neuroscience · 2020Review
- The Biology of General Anesthesia from Paramecium to Primate.Current biology : CB · 2019Review
- Article
- SPINDLE: End-to-end learning from EEG/EMG to extrapolate animal sleep scoring across experimental settings, labs and species.PLoS computational biology · 2019Article
- Exploring phylogeny to find the function of sleep.Nature reviews. Neuroscience · 2019Review
- Roles for sleep in memory: insights from the fly.Current opinion in neurobiology · 2019Review
- Electrophysiological characterization of sleep/wake, activity and the response to caffeine in adult cynomolgus macaques.Neurobiology of sleep and circadian rhythms · 2019Article
- The origins and evolution of sleep.The Journal of experimental biology · 2018Review
- Time for Bed: Genetic Mechanisms Mediating the Circadian Regulation of Sleep.Trends in genetics : TIG · 2018Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
STUDY
objectiveTo characterize sleep in the marine mollusk, Aplysia californica.
designAnimal behavior and activity were assessed using video recordings to measure activity, resting posture, resting place preference, and behavior after rest deprivation. Latencies for behavioral responses were measured for appetitive and aversive stimuli for animals in the wake and rest states.
settingCircadian research laboratory for Aplysia. PATIENTS OR
participantsA. californica from the Pacific Ocean.
interventionsN/A. MEASUREMENTS AND
resultsAplysia rest almost exclusively during the night in a semi-contracted body position with preferential resting locations in the upper corners of their tank. Resting animals demonstrate longer latencies in head orientation and biting in response to a seaweed stimulus and less frequent escape response steps following an aversive salt stimulus applied to the tail compared to awake animals at the same time point. Aplysia exhibit rebound rest the day following rest deprivation during the night, but not after similar handling stimulation during the day.
conclusionsResting behavior in Aplysia fulfills all invertebrate characteristics of sleep including: (1) a specific sleep body posture, (2) preferred resting location, (3) reversible behavioral quiescence, (4) elevated arousal thresholds for sensory stimuli during sleep, and (5) compensatory sleep rebound after sleep deprivation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.