ArticleJournal of the Royal Society, Interface2014
A mathematical model of collagen lattice contraction.
Article in Journal of the Royal Society, Interface, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Emergent depth-mechanosensing of epithelial collectives regulates cell clustering and dispersal on layered matrices.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Models for Implant-Induced Capsular Contracture Post Breast Cancer Surgery.Bulletin of mathematical biology · 2023Article
- Dynamics of Fibril Collagen Remodeling by Tumor Cells: A Model of Tumor-Associated Collagen Signatures.Cells · 2023Article
- Mathematical Modeling Can Advance Wound Healing Research.Advances in wound care · 2021Review
- Matrix-transmitted paratensile signaling enables myofibroblast-fibroblast cross talk in fibrosis expansion.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Modeling mammary organogenesis from biological first principles: Cells and their physical constraints.Progress in biophysics and molecular biology · 2016Review
- Mathematical models of wound healing and closure: a comprehensive review.Medical & biological engineering & computing · 2016Review
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
Two mathematical models for fibroblast-collagen interaction are proposed which reproduce qualitative features of fibroblast-populated collagen lattice contraction. Both models are force based and model the cells as individual entities with discrete attachment sites; however, the collagen lattice is modelled differently in each model. In the collagen lattice model, the lattice is more interconnected and formed by triangulating nodes to form the fibrous structure. In the collagen fibre model, the nodes are not triangulated, are less interconnected, and the collagen fibres are modelled as a string of nodes. Both models suggest that the overall increase in stress of the lattice as it contracts is not the cause of the reduced rate of contraction, but that the reduced rate of contraction is due to inactivation of the fibroblasts.
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