Evidence map›Paper›PMID 25142516›Full record

ArticleJournal of the Royal Society, Interface2014

The interplay between cooperativity and diversity in model threshold ensembles.

Javier Cervera, José A Manzanares, Salvador Mafe

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the Royal Society, Interface, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Javier CerveraDepartament de Termodinàmica, Universitat de València, Burjassot 46100, Spain javier.cervera@uv.es.
José A ManzanaresDepartament de Termodinàmica, Universitat de València, Burjassot 46100, Spain.
Salvador MafeDepartament de Termodinàmica, Universitat de València, Burjassot 46100, Spain smafe@uv.es.
Universitat de València · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The interplay between cooperativity and diversity is crucial for biological ensembles because single molecule experiments show a significant degree of heterogeneity and also for artificial nanostructures because of the high individual variability characteristic of nanoscale units. We study the cross-effects between cooperativity and diversity in model threshold ensembles composed of individually different units that show a cooperative behaviour. The units are modelled as statistical distributions of parameters (the individual threshold potentials here) characterized by central and width distribution values. The simulations show that the interplay between cooperativity and diversity results in ensemble-averaged responses of interest for the understanding of electrical transduction in cell membranes, the experimental characterization of heterogeneous groups of biomolecules and the development of biologically inspired engineering designs with individually different building blocks.

Indexed as

Models, TheoreticalBioengineeringCell MembraneComputer SimulationElectric ConductivityNanostructuresSystems Biologybiological diversitycooperativity phenomenathreshold response

Identifiers

PMID25142516
PMCPMC4233720
OpenAlexW2115908553

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.