ArticleBMC genomics2014
The genome of Eimeria falciformis--reduction and specialization in a single host apicomplexan parasite.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Systematic Review and Meta-Analysis of the Prevalence, Species Distribution and Risk Factors of Eimeria spp. in Iranian Livestock.Veterinary medicine and science · 2025Pooled it
- Organellar genome dynamics of exogenous stages of Eimeria tenella.Parasites & vectors · 2024Article
- Study on the alleviative effect ofInfection and immunity · 2024Article
- Persea americana extract protects intestinal tissue from Eimeria papillata-induced murine Infection.BMC veterinary research · 2023Article
- Amplicon sequencing allows differential quantification of closely related parasite species: an example from rodent Coccidia (Eimeria).Parasites & vectors · 2023Article
- What Do We Know about Surface Proteins of Chicken ParasitesLife (Basel, Switzerland) · 2023Review
- Eimeria falciformis secretes extracellular vesicles to modulate proinflammatory response during interaction with mouse intestinal epithelial cells.Parasites & vectors · 2022Article
- Mobilome of Apicomplexa Parasites.Genes · 2022Article
- Shifting focus from resistance to disease tolerance: A review on hybrid house mice.Ecology and evolution · 2022Review
- DNA-based quantification and counting of transmission stages provides different but complementary parasite load estimates: an example from rodent coccidia (Eimeria).Parasites & vectors · 2022Article
- Eimeria proteins: order amidst disorder.Parasites & vectors · 2022Review
- Genetic and biological characterisation of three cryptic Eimeria operational taxonomic units that infect chickens (Gallus gallus domesticus).International journal for parasitology · 2021Article
- Article
- ExploringGenes · 2020Review
- GeneralistEcology and evolution · 2020Article
- Comparisons of the Sexual Cycles for the Coccidian ParasitesFrontiers in cellular and infection microbiology · 2020Review
- Poultry Coccidiosis: Design and Interpretation of Vaccine Studies.Frontiers in veterinary science · 2020Review
- Detection and quantification of house mouseInternational journal for parasitology. Parasites and wildlife · 2019Article
- Dual-Family Peptidylprolyl Isomerases (Immunophilins) of Select Monocellular Organisms.Biomolecules · 2018Review
- RANGER-DTL 2.0: rigorous reconstruction of gene-family evolution by duplication, transfer and loss.Bioinformatics (Oxford, England) · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe phylum Apicomplexa comprises important unicellular human parasites such as Toxoplasma and Plasmodium. Eimeria is the largest and most diverse genus of apicomplexan parasites and some species of the genus are the causative agent of coccidiosis, a disease economically devastating in poultry. We report a complete genome sequence of the mouse parasite Eimeria falciformis. We assembled and annotated the genome sequence to study host-parasite interactions in this understudied genus in a model organism host.
resultsThe genome of E. falciformis is 44 Mb in size and contains 5,879 predicted protein coding genes. Comparative analysis of E. falciformis with Toxoplasma gondii shows an emergence and diversification of gene families associated with motility and invasion mainly at the level of the Coccidia. Many rhoptry kinases, among them important virulence factors in T. gondii, are absent from the E. falciformis genome. Surface antigens are divergent between Eimeria species. Comparisons with T. gondii showed differences between genes involved in metabolism, N-glycan and GPI-anchor synthesis. E. falciformis possesses a reduced set of transmembrane transporters and we suggest an altered mode of iron uptake in the genus Eimeria.
conclusionsReduced diversity of genes required for host-parasite interaction and transmembrane transport allow hypotheses on host adaptation and specialization of a single host parasite. The E. falciformis genome sequence sheds light on the evolution of the Coccidia and helps to identify determinants of host-parasite interaction critical for drug and vaccine development.
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Registered trials
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