ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2014
miR-141 suppresses the growth and metastasis of HCC cells by targeting E2F3.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- RNA nanotherapeutics for hepatocellular carcinoma treatment.Theranostics · 2025Review
- MicroRNA-141-regulated KLK10 and TNFSF-15 gene expression in hepatoblastoma cells as a novel mechanism in liver carcinogenesis.Scientific reports · 2024Article
- MicroRNA‑141 inhibits the differentiation of bone marrow‑derived mesenchymal stem cells in steroid‑induced osteonecrosis via E2F3.Molecular medicine reports · 2022Article
- Expression and prognostic value of E2F3 transcription factor in non-small cell lung cancer.Oncology letters · 2021Article
- microRNAs: Key players in virus-associated hepatocellular carcinoma.Journal of cellular physiology · 2019Review
- MicroRNA-141 ameliorates alcoholic hepatitis‑induced intestinal injury and intestinal endotoxemia partially via a TLR4-dependent mechanism.International journal of molecular medicine · 2019Article
- MicroRNA-183 and microRNA-141 are potential risk factors for poor prognosis in patients with nasopharyngeal carcinoma.Oncology letters · 2019Article
- Analysis of microarrays of miR-34a and its identification of prospective target gene signature in hepatocellular carcinoma.BMC cancer · 2018Article
- miR-144 suppresses proliferation and induces apoptosis of osteosarcoma cells via direct regulation of mTOR expression.Oncology letters · 2018Article
- Role of exosomal small RNA in prostate cancer metastasis.Cancer management and research · 2018Review
- A qRT-PCR and Gene Functional Enrichment Study Focused on Downregulation of miR-141-3p in Hepatocellular Carcinoma and Its Clinicopathological Significance.Technology in cancer research & treatment · 2017Article
- MicroRNA-141 is a tumor regulator and prognostic biomarker in human glioblastoma.Oncology letters · 2017Article
- Review
- Role of the long non-coding RNA HOTAIR in hepatocellular carcinoma.Oncology letters · 2017Article
- Epigenetics in NG2 glia cells.Brain research · 2016Review
- miR-874 suppresses the proliferation and metastasis of osteosarcoma by targeting E2F3.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- MiR-30a regulates the proliferation, migration, and invasion of human osteosarcoma by targeting Runx2.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Exosomal microRNA-141 is upregulated in the serum of prostate cancer patients.OncoTargets and therapy · 2016Article
- miR-503 inhibits cell proliferation and induces apoptosis in colorectal cancer cells by targeting E2F3.International journal of clinical and experimental pathology · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) function as essential post-transcriptional modulators of gene expression involved in a wide range of physiologic and pathologic states, including cancer. Numerous miRNAs have been deregulated in hepatocellular carcinoma (HCC). Here, we investigated the role of miR-141 in HCC. Decreased expression of miR-141 was observed in both HCC tissues and cell lines. Ectopic overexpression of miR-141 reduced proliferation, migration, and invasion of HCC cells. E2F transcription factor 3 (E2F3) was confirmed to be a target of miR-141 in HCC cells. Moreover, restoration of E2F3 significantly reversed the tumor suppressive effects of miR-141. Our results suggest a critical role of miR-141 in suppressing metastasis of HCC cells by targeting E2F3.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.