ArticleDigestive diseases and sciences2015
Correlation of Helicobacter pylori genotypes with gastric histopathology in the central region of a South-European country.
Article in Digestive diseases and sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Review
- Pathogenicity ofWorld journal of clinical oncology · 2025Review
- The Effect ofPathogens (Basel, Switzerland) · 2025Article
- Review
- Comparison of Drug Resistance of Helicobacter pylori Between Children and Adults in Jilin, China.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2021Article
- Antibiotic Resistance and Genotypes ofJournal of clinical medicine · 2019Article
- [Prevalence of Helicobacter pylori cagA, vacA, and iceA genotypes in children with gastroduodenal diseases].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016Article
- Review
- Relationship between the iceA gene of Helicobacter pylori and clinical outcomes.Therapeutics and clinical risk management · 2016Article
- Diagnosis of Helicobacter pylori infection: Current options and developments.World journal of gastroenterology · 2015Review
- Article
- The effect of virulence genotypes ofSaudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOutcome of Helicobacter pylori (H. pylori) infection results from interaction of multiple variables including host, environmental and bacterial-associated virulence factors.
aimThis study aimed to investigate the correlation of cagA, cagE, vacA, iceA and babA2 genotypes with gastric histopathology and disease phenotype in the central region of a South-European country.
methodsThis prospective study involved 148 infected patients (110 female; mean age 43.5 ± 13.4 years) submitted to endoscopy with corpus and antrum biopsies. H. pylori was cultured and DNA extracted from the isolates. Genotypes were determined by PCR. Histopathological features were graded according to the updated Sydney system and OLGA/OLGIM classification. Only patients with single H. pylori genotypes and complete histopathological results were included.
resultsAntrum samples presented higher degrees of atrophy, intestinal metaplasia, chronic inflammation and neutrophil activity. Genotype distribution was as follows: cagA-31.8 %; cagE-45.9 %; vacA s1a-24.3 %; vacA s1b-19.6 %; vacA s1c-0.7 %; vacA s2-55.4 %; vacA m1-20.9 %; vacA m2-79.1 %; vacA s1m1-18.9 %; vacA s1m2-25.7 %; vacA s2m1-2 %; vacA s2m2-53.4 %; iceA1-33.8 %; iceA2-66.2 %; babA2-12.2 %. CagA genotype was significantly associated with higher degrees of intestinal metaplasia, neutrophil activity, chronic inflammation and OLGIM stages. BabA2 was linked with higher H. pylori density. Strains with vacA s1m1 or vacA s1m1 + cagA positive genotypes had a significant association with peptic ulcer and vacA s2m2 with iron-deficient anemia.
conclusionscagA, vacA s1m1 and babA2 genotypes are relatively rare in the central region of Portugal. cagA-positive strains are correlated with more severe histopathological modifications. This gene is commonly associated with vacA s1m1, and such isolates are frequently found in patients with peptic ulcer.
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