ReviewHead and neck pathology2015
Canalicular adenoma: a clinicopathologic and immunohistochemical analysis of 67 cases with a review of the literature.
Review in Head and neck pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- SOX10 Expression in Primary Salivary Gland Tumors: A Meta-Analysis.Head and neck pathology · 2026Pooled it
- Imaging of benign salivary gland tumors: an update based on the fifth WHO classification, with a focus on rare histologic types and newly listed entities-part I.Japanese journal of radiology · 2026Review
- Transcriptomic comparative study between canalicular adenoma and HMGA2::WIF1 canalicular-like pleomorphic adenoma.The Journal of pathology · 2026Article
- Canalicular Adenomas of Minor Salivary Glands: A Systematic Review of Case Reports and Case Series.Journal of clinical medicine · 2026Review
- Benign Epithelial Salivary Neoplasms: Single-Centered Histopathologic and Clinicodemographic Romanian Retrospective Study.Clinics and practice · 2025Article
- Article
- Salivary gland pathologies: evolution in classification and association with unique genetic alterations.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Review
- A case of canalicular adenoma with anemia.Journal of surgical case reports · 2022Article
- Canalicular adenoma: palatal presentation of an uncommon lesion.BMJ case reports · 2021Article
- Synchronous Multifocal Canalicular Adenomas.Head and neck pathology · 2021Article
- Canalicular adenoma of the tongue: report of a unique case.The Pan African medical journal · 2021Article
- Canalicular adenoma with unicystic morphology. A rare entity.Journal of clinical and experimental dentistry · 2021Article
- Canalicular adenoma of the hard palate: A rare case report.Dental research journal · 2021Article
- Challenges in Minor Salivary Gland Biopsies: A Practical Approach to Problematic Histologic Patterns.Head and neck pathology · 2019Review
- Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours.Advances in therapy · 2019Review
- Synchronous Polymorphous Adenocarcinoma and Canalicular Adenoma on the Upper Lip: An Unusual Presentation and Immunohistochemical Analysis.Head and neck pathology · 2018Article
- Angioleiomyoma of the upper lip.BMJ case reports · 2017Article
- Pleomorphic Adenoma of the Upper Lip: A Case Report.Saudi journal of medicine & medical sciencesArticle
Corrections and comments
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Authors and funding
7 authors at 7 institutions in 1 country.
Funding
Abstract
There is a lack of a comprehensive immunohistochemical (IHC) analysis of canalicular adenoma (CanAd), especially when combined with a description of the unique histologic features. Given the usual small biopsies, IHC may be useful in distinguishing CanAd from other tumors in the differential diagnosis. Retrospective. The patients included 54 females and 13 males (4.2:1), aged 43-90 years, with a mean age at presentation of 69.9 years. Clinical presentation was generally a mass (n = 61) slowly increasing in size (mean 38.5 months), affecting the upper lip (n = 46), buccal mucosa (n = 17) or palate (n = 4), involving the right (n = 29), left (n = 24) or midline (n = 9), without any major salivary gland tumors. The tumors ranged in size from 0.2 to 3 cm (mean 1.2 cm). Most tumors were multilobular or bosselated (76 %), often surrounded by a capsule. Histologically, the tumors were characterized by cystic spaces, tumor cords with beading, tubule formation, and by the presence of luminal squamous balls (n = 41). The cells were cuboidal to columnar with stippled chromatin. Mitoses were inconspicuous. A myxoid stroma (n = 64), sclerosis (n = 42), luminal hemorrhage (n = 51), and luminal microliths (calcifications) (n = 33) were characteristic. Nine (13.4 %) were multifocal. CanAd showed the following characteristic immunohistochemistry findings: CK-pan and S100 protein (strong, diffuse reaction); peripheral or luminal GFAP reaction; CK5/6 and p16 luminal squamous ball reaction; SOX10 nuclear reaction; cytoplasmic p63 reaction. CanAd are unique minor salivary gland tumors showing a distinct architecture and phenotype. They predilect to older women, with the majority multilobulated and affecting the upper lip, multifocal in 13 %; no major salivary gland tumors were identified. S100 protein, CK-pan, GFAP and SOX10 are positive, with luminal squamous balls highlighted by CK5/6 or p16.
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