Evidence map›Paper›PMID 25140905›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2014

Low-level Viremia early in HIV infection.

Iris Chen, Vanessa Cummings, Jessica M Fogel, Mark A Marzinke, William Clarke, Matthew B Connor, Sam Griffith, Susan Buchbinder, Steven Shoptaw, Carlos Del Rio and 6 more

Open access · greenAbstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Determination of HIV Status in African Adults With Discordant HIV Rapid Tests.Journal of acquired immune deficiency syndromes (1999) · 2015
    Article
  10. Performance of the fourth-generation Bio-Rad GS HIV Combo Ag/Ab enzyme immunoassay for diagnosis of HIV infection in Southern Africa.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 12 institutions in 1 country.

Iris Chen*Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD; †Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA; ‡Science Facilitation Department, FHI 360, Research Triangle Park, NC; §San Francisco Department of Public Health, Bridge HIV, San Francisco, CA; ‖Department of Family Medicine, University of California Los Angeles, Los Angeles, CA; ¶Department of Global Health, Emory University Rollins School of Public Health, Atlanta, GA; #Department of Epidemiology and Biostatistics, The George Washington University, Washington, DC; **Department of Medicine, Harlem Hospital, Columbia University, Mailman School of Public Health, New York, NY; ††Graduate School of Social Work, Loyola University Chicago, Chicago, IL; ‡‡The Fenway Institute, Fenway Health/Infectious Disease Division, Beth Israel Deaconess Medical Center/Department of Medicine, Harvard Medical School, Boston, MA; §§Laboratory of Infectious Disease Prevention, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY.
Vanessa Cummings
Jessica M Fogel
Mark A Marzinke
William Clarke
Matthew B Connor
Sam Griffith
Susan Buchbinder
Steven Shoptaw
Carlos Del Rio
Manya Magnus
Sharon Mannheimer
Darrell P Wheeler
Kenneth H Mayer
Beryl A Koblin
Susan H Eshleman
Johns Hopkins Medicine · USJohns Hopkins University · USEmory University · USFamily Health International 360 · USFenway Health · USGeorge Washington University · USHarlem Hospital Center · USInfectious Disease Research Institute · USLoyola University Chicago · USNew York Blood Center · USSan Francisco Department of Public Health · USUniversity of California, Los Angeles · US

Funding

LOC: HIV Prevention Trials NetworkUM1AI068619 · NIAID · FAMILY HEALTH INTERNATIONAL · PI MYRON Scott COHEN, Sinead Delany-Moretlwe · 2011 to 2026
$779.5M
SDMC: HPTN 084 Pregnancy SupplementUM1AI068617 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Elizabeth Renata Brown, Deborah J Donnell · 2011 to 2026
$204.9M
LC: HIV Prevention Trials Network - Laboratory Support for the SARS-CoV-2 Seroprevalence Study (CoVPN 5002)UM1AI068613 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SUSAN H ESHLEMAN, Mark A Marzinke · 2011 to 2026
$100.2M
HIV Prevention trials Network (HPTN) Coordinating and Operations CenterU01AI068619 · NIAID · FAMILY HEALTH INTERNATIONAL · PI VERMUND, STEN H. · 2006 to 2010
$72.7M
Ujima Mentoring ProgramP30MH062246 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Sheri Ann Lippman · 2001 to 2026
$57.4M
UCLA Rapid, Relevant, Rigorous Implementation Science HubP30MH058107 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAPHAEL J LANDOVITZ · 1997 to 2026
$53.5M
Emory HIV/AIDS Clinical Trials UnitUM1AI069418 · NIAID · EMORY UNIVERSITY · PI Colleen F Kelley · 2012 to 2026
$46.0M
Columbia Partnership for Prevention and Control of HIV/AIDS Clinical Trials UnitUM1AI069470 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAGDALENA ELZBIETA SOBIESZCZYK · 2012 to 2026
$44.8M
San Francisco Vaccine and Prevention UnitUM1AI069496 · NIAID · PUBLIC HEALTH FOUNDATION ENTERPRISES · PI Susan Buchbinder, Diane V Havlir · 2012 to 2026
$30.5M
Leadership for HIV/AIDS Clinical Trials Networks; HIV Prevention Trials NetworkU01AI068617 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DONNELL, DEBORAH J · 2006 to 2010
$28.8M
HIV Prevention Trials Network: Network LaboratoryU01AI068613 · NIAID · JOHNS HOPKINS UNIVERSITY · PI ESHLEMAN, SUSAN H · 2006 to 2010
$16.5M
Columbia Collaborative HIV/AIDS Clinical Trials UnitU01AI069470 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HAMMER, SCOTT M · 2007 to 2011
$15.4M
NIAID NIH HHS R01 AI095068NIAID NIH HHS R01-AI095068NIAID NIH HHS U01-AI068613NIAID NIH HHS U01-AI068617NIAID NIH HHS U01-AI068619NIAID NIH HHS U01 AI069418NIAID NIH HHS UM1 AI068613NIAID NIH HHS UM1-AI068613NIAID NIH HHS UM1 AI068617NIAID NIH HHS UM1-AI068617NIAID NIH HHS UM1 AI068619NIAID NIH HHS UM1-AI068619NIAID NIH HHS UM1 AI069418NIAID NIH HHS UM1 AI069470NIAID NIH HHS UM1 AI069496NICHD NIH HHS R25 HD045810NIGMS NIH HHS T32 GM008752NIMH NIH HHS P30 MH058107NIMH NIH HHS P30 MH062246
6 · The paper itself

Abstract

HIV RNA levels are usually high early in HIV infection. In the HPTN 061 study, men were tested for HIV infection every 6 months; 6 (21.4%) of 28 men who acquired HIV infection during the study had low or undetectable HIV RNA at the time of HIV diagnosis. Antiretroviral drugs were not detected at the time of HIV diagnosis. False-negative HIV test results were obtained for 2 men using multiple assays. Antiretroviral drug resistance mutations were detected in HIV from 1 man. Additional studies are needed to identify factors associated with low HIV RNA levels during early HIV infection.

Indexed as

AdolescentAdultHIV InfectionsHumansMaleRNA, ViralViral LoadViremiaYoung AdultRNA, Viral

Identifiers

PMID25140905
PMCPMC4213245
OpenAlexW2072251244

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.