ArticleOrganic letters2014
Synthesis of isocoumarins with different substituted patterns via Passerini-aldol sequence.
Article in Organic letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Stefano Marcaccini: a pioneer in isocyanide chemistry.Molecular diversity · 2024Review
- The 100 facets of the Passerini reaction.Chemical science · 2021Review
- Unexpected isocyanide-based three-component bicyclization for the stereoselective synthesis of densely functionalized pyrano[3,4-c]pyrroles.Chemical communications (Cambridge, England) · 2016Article
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6 authors.
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Abstract
An efficient combination between the Passerini three-component reaction and aldol condensation has been developed for the synthesis of bicyclic isocoumarins with different substituted patterns via solvent-dependent domino pathways. These two operationally friendly methods simultaneously install C-O and C-C bonds in a one-pot manner, allowing the utilization of low-cost and readily accessible 2-formylbenzoic acid, isocyanides, and arylglyoxals. Mechanisms of formation of different substituted isocoumarin derivatives are also proposed.
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