Evidence map›Paper›PMID 25140667›Full record

ArticleThe American Journal of dermatopathology2015

Langerhans Cell Hyperplasia From Molluscum Contagiosum.

Alyn D Hatter, Xin Zhou, Kord Honda, Daniel L Popkin

Abstract readCase Reports
In one paragraph

Article in The American Journal of dermatopathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. This "Case reports in dermatology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Alyn D HatterDepartment of Dermatology, Case Western Reserve University, Cleveland, OH.
Xin Zhou
Kord Honda
Daniel L Popkin
Case Western Reserve University · US

Funding

Vitamin D endocrine system and Protection Against Skin TumorlgenesisP30AR039750 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI WARD, NICOLE LEANNE · 1988 to 2015
$9.1M
Genetic Dissection of Viral PersistenceK08AI091641 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI POPKIN, DANIEL LEWIS · 2011 to 2013
$357k
NIAID NIH HHS AI091641NIAID NIH HHS K08 AI091641NIAMS NIH HHS P30 AR039750NIAMS NIH HHS P30AR039750
6 · The paper itself

Abstract

Langerhans cell histiocytosis (LCH) carries a prognosis, which ranges from benign to potentially fatal. There is currently little framework to decipher metrics, which predict the benign versus aggressive nature of LCH. We wanted to determine whether molluscum contagiosum virus (MCV) DNA could be isolated from a cutaneous lesion, demonstrating Langerhans cell hyperplasia resembling LCH in a patient with both. Polymerase chain reaction on biopsy-proven MCV and the hyperplastic lesion has been performed. Two specific regions within the MCV genome were detected from both biopsies. The authors report our findings and suggest that some MCV can produce histological lesions resembling LCH, similar to the literature on scabies mimicking LCH. Efforts to find a reactive "driver" in LCH may significantly inform the clinical scenario.

Indexed as

AdolescentAntigens, CD1DNA, ViralHistiocytosis, Langerhans-CellHumansHyperplasiaLangerhans CellsMaleMolluscum ContagiosumMolluscum contagiosum virusS100 ProteinsAntigens, CD1CD1a antigenDNA, ViralS100 Proteins

Identifiers

PMID25140667
PMCPMC4334759
OpenAlexW2323890025

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.