ArticlePloS one2014
Associations between longer habitual day napping and non-alcoholic fatty liver disease in an elderly Chinese population.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 35 citations in OpenAlex.
- Combined nocturnal sleep pattern and napping duration in relation to metabolic dysfunction-associated steatotic liver disease risk and prediction in type 2 diabetes mellitus.Diabetology & metabolic syndrome · 2026Article
- Association between sleep duration and risk of nonalcoholic fatty liver disease: A systematic review and meta-analysis.Preventive medicine reports · 2025Review
- Impact of sleep chronotype on blood pressure and metabolic markers.Frontiers in neurology · 2025Article
- Long daytime napping: A silent danger for hypertensive individuals.European journal of neurology · 2024Article
- Daytime napping and the incidence of Parkinson's disease: a prospective cohort study with Mendelian randomization.BMC medicine · 2024Article
- Excessive Daytime Napping Increases the Risk of Non-Alcoholic Fatty Liver Disease: A Meta-Analysis and a Mendelian Randomization Study.Nature and science of sleep · 2024Article
- Sleep characteristics of middle-aged adults with non-alcoholic fatty liver disease: findings from the Shahrekord PERSIAN cohort study.BMC public health · 2023Article
- A double-edged sword: the association of daytime napping duration and metabolism related diseases in a Chinese population.European journal of clinical nutrition · 2021Article
- Circadian rhythms: a possible new player in non-alcoholic fatty liver disease pathophysiology.Journal of molecular medicine (Berlin, Germany) · 2019Review
- Role of the Circadian Clock in the Metabolic Syndrome and Nonalcoholic Fatty Liver Disease.Digestive diseases and sciences · 2018Review
- Exercising the hepatobiliary-gut axis. The impact of physical activity performance.European journal of clinical investigation · 2018Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextBoth longer habitual day napping and Non-Alcoholic Fatty Liver Disease (NAFLD) are associated with diabetes and inflammation, but the association between day napping and NAFLD remains unexplored.
objectiveTo investigate the association between the duration of habitual day napping and NAFLD in an elderly Chinese population and to gain insight into the role of inflammatory cytokines in this association. DESIGN AND
settingWe conducted a series of cross-sectional studies of the community population in Chongqing, China, from 2011 to 2012.
participantsAmong 6998 participants aged 40 to 75 years, 6438 eligible participants were included in the first study and analyzed to observe the association between day napping duration and NAFLD. In a separate study, 80 non-nappers and 90 nappers were selected to identify the role of inflammatory cytokines in this association. Logistic regression models were used to examine the odds ratios (ORs) of day nap duration with NAFLD.
resultsDay nappers had a significantly higher prevalence of NAFLD (P<0.001). Longer day napping duration was associated in a dose-dependent manner with NAFLD (P trend <0.001). After adjustment for potential confounders, the ORs were 1.67 (95% CI 1.13-2.46) for those reporting 0.5-1 h and 1.49 (95% CI 1.01-2.19) for those reporting >1 h of day napping compared with individuals who did not take day naps (all P<0.05). Longer-duration day nappers had higher levels of IL-6 and progranulin (PGRN) but lower levels of Secreted frizzled-related protein-5 (SFRP5, all P trend <0.001). After adjusting for IL-6, PGRN, and SFRP5, the association between day napping duration and NAFLD disappeared (all P>0.05).
conclusionLonger day napping duration is associated with a higher prevalence of NAFLD, and inflammatory cytokines may be an essential link between day napping and NAFLD.
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