ArticleRevista brasileira de cirurgia cardiovascular : orgao oficial da Sociedade Brasileira de Cirurgia Cardiovascular
Myocardial regeneration after implantation of porcine small intestinal submucosa in the left ventricle.
Article in Revista brasileira de cirurgia cardiovascular : orgao oficial da Sociedade Brasileira de Cirurgia Cardiovascular. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 5 citations in OpenAlex.
- Dual human iPSC-derived cardiac lineage cell-seeding extracellular matrix patches promote regeneration and long-term repair of infarcted hearts.Bioactive materials · 2023Article
- Cell-Based Therapies for Myocardial Regeneration in Heart Failure: 20 Years of Debate.Brazilian journal of cardiovascular surgery · 2020Article
- In Vivo Assessment of Decellularized Porcine Myocardial Slice as an Acellular Cardiac Patch.ACS applied materials & interfaces · 2019Article
- Regeneration of Tracheal Tissue in Partial Defects Using Porcine Small Intestinal Submucosa.Stem cells international · 2018Article
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Authors and funding
13 authors at 2 institutions in 1 country.
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Abstract
introductionMost cardiomyocytes do not regenerate after myocardial infarction. Porcine small intestinal submucosa has been shown to be effective in tissue repair.
objectiveTo evaluate myocardial tissue regeneration and functional effects of SIS implantation in pigs after left ventriculotomy.
methodsFifteen pigs were assigned to two groups: porcine small intestinal submucosa (SIS) (N=10) and control (N=5). The SIS group underwent a mini sternotomy, left ventriculotomy and placement of a SIS patch. The control group underwent a sham procedure. Echocardiography was performed before and 60 days after the surgical procedure. Histological analysis was performed with hematoxylin-eosin stain and markers for actin 1A4, anti sarcomeric actin, connexin43 and factor VIII.
resultsWeight gain was similar in both groups. Echocardiography analysis revealed no difference between groups regarding end diastolic and systolic diameters and left ventricular ejection fraction, both pre (P=0.118, P=0.313, P=0.944) and post procedure (P=0.333, P=0.522, P=0.628). Both groups showed an increase in end diastolic (P<0,001 for both) and systolic diameter 60 days after surgery (P=0.005, SIS group and P=0.004, control group). New cardiomyocytes, blood vessels and inflammatory reactions were histologically identified in the SIS group.
conclusionSIS implantation in pigs after left ventriculotomy was associated with angiomuscular regeneration and no damage in cardiac function.
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