ReviewBioMed research international2014
Autophagy in alcohol-induced multiorgan injury: mechanisms and potential therapeutic targets.
Review in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Finite Element Modeling of Cochlear Mechanics: A Systematic Review.Annals of biomedical engineering · 2026Pooled it
- Integrating Strategy of Network Pharmacology, Molecular Dynamics Simulation, and Experimental Verification to Investigate the Potential Mechanism ofFoods (Basel, Switzerland) · 2025Article
- Roles of Oxidative Stress and Autophagy in Alcohol-Mediated Brain Damage.Antioxidants (Basel, Switzerland) · 2025Review
- Choline dehydrogenase interacts with SQSTM1 to activate mitophagy and promote coelomocyte survival inZoological research · 2023Article
- Autophagy, Oxidative Stress, and Alcoholic Liver Disease: A Systematic Review and Potential Clinical Applications.Antioxidants (Basel, Switzerland) · 2023Review
- Non-apoptotic caspase activation ensures the homeostasis of ovarian somatic stem cells.EMBO reports · 2023Article
- Liver-adipose tissue crosstalk in alcohol-associated liver disease: The role of mTOR.Liver research (Beijing, China) · 2022Article
- Protection effect of thymosin β4 on ethanol injury in corneal stromal keratocyte.BMC ophthalmology · 2022Article
- Trehalose activates hepatic transcription factor EB (TFEB) but fails to ameliorate alcohol-impaired TFEB and liver injury in mice.Alcoholism, clinical and experimental research · 2021Article
- The Anaerobic Product Ethanol Promotes Autophagy-Dependent Submergence Tolerance inInternational journal of molecular sciences · 2020Article
- Endoplasmic reticulum stress and autophagy dysregulation in alcoholic and non-alcoholic liver diseases.Clinical and molecular hepatology · 2020Review
- Epigenetic mechanisms underlying pathobiology of alcohol use disorder.Current pathobiology reports · 2020Article
- Influence of Chronic Ethanol Consumption on Apoptosis and Autophagy Following Transient Focal Cerebral Ischemia in Male Mice.Scientific reports · 2020Article
- Role of Mechanistic Target of Rapamycin and Autophagy in Alcohol-Induced Adipose Atrophy and Liver Injury.The American journal of pathology · 2020Article
- Hepatic NPC1L1 overexpression attenuates alcoholic autophagy in mice.Molecular medicine reports · 2019Article
- MicroRNA-222 reprogrammed cancer-associated fibroblasts enhance growth and metastasis of breast cancer.British journal of cancer · 2019Article
- Murine macrophage autophagy protects against alcohol-induced liver injury by degrading interferon regulatory factor 1 (IRF1) and removing damaged mitochondria.The Journal of biological chemistry · 2019Article
- HEMA Effects on Autophagy Mechanism in Human Dental Pulp Stem Cells.Materials (Basel, Switzerland) · 2019Article
- Decreased Macrophage Autophagy Promotes Liver Injury and Inflammation from Alcohol.Alcoholism, clinical and experimental research · 2019Article
- Role and mechanisms of autophagy in alcohol-induced liver injury.Advances in pharmacology (San Diego, Calif.) · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Autophagy is a genetically programmed, evolutionarily conserved intracellular degradation pathway involved in the trafficking of long-lived proteins and cellular organelles to the lysosome for degradation to maintain cellular homeostasis. Alcohol consumption leads to injury in various tissues and organs including liver, pancreas, heart, brain, and muscle. Emerging evidence suggests that autophagy is involved in alcohol-induced tissue injury. Autophagy serves as a cellular protective mechanism against alcohol-induced tissue injury in most tissues but could be detrimental in heart and muscle. This review summarizes current knowledge about the role of autophagy in alcohol-induced injury in different tissues/organs and its potential molecular mechanisms as well as possible therapeutic targets based on modulation of autophagy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.