ArticleInternational journal of nephrology2014
High Steroid Sensitivity among Children with Nephrotic Syndrome in Southwestern Nigeria.
Article in International journal of nephrology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Steroid-sensitive nephrotic syndrome: Do children with early onset of <4 years of age, really need standard therapy?Journal of family medicine and primary care · 2025Article
- Article
- Idiopathic Nephrotic Syndrome in Children in Chad: Epidemiology and Clinical Outcomes.Journal of clinical medicine · 2023Article
- Hiding in plain sight: genetics of childhood steroid-resistant nephrotic syndrome in Sub-Saharan Africa.Pediatric nephrology (Berlin, Germany) · 2023Review
- Trends in the epidemiology of childhood nephrotic syndrome in Africa: A systematic review.Global epidemiology · 2021Review
- Management of idiopathic childhood nephrotic syndrome in sub-Saharan Africa: Ibadan consensus statement.Kidney international · 2021Article
- Timing and predictive factors of developing chronic kidney disease in childhood-onset idiopathic nephrotic syndrome: an Asian experience.Singapore medical journal · 2020Article
- Changing epidemiology of nephrotic syndrome in Nigerian children: A cross-sectional study.PloS one · 2020Article
- Childhood nephrotic syndrome at the University of Abuja Teaching Hospital, Abuja, Nigeria: a preliminary report supports high steroid responsiveness.Sudanese journal of paediatrics · 2019Article
- Prospects of genetic testing for steroid-resistant nephrotic syndrome in Nigerian children: a narrative review of challenges and opportunities.International journal of nephrology and renovascular disease · 2019Review
- The incidence of the nephrotic syndrome in childhood in Germany.Clinical and experimental nephrology · 2018Article
- Proteinuric kidney disease in children at Queen Elizabeth Central Hospital, Malawi.BMC nephrology · 2018Article
- A unified pathogenesis for kidney diseases, including genetic diseases and cancers, by the protein-homeostasis-system hypothesis.Kidney research and clinical practice · 2017Review
- Cyclosporine in the treatment of childhood idiopathic steroid resistant nephrotic syndrome: a single centre experience in Nigeria.The Pan African medical journal · 2016Article
- Trends in the histopathology of childhood nephrotic syndrome in Ibadan Nigeria: preponderance of idiopathic focal segmental glomerulosclerosis.BMC nephrology · 2015Article
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3 authors.
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Abstract
Recent reports from both Caucasian and black populations suggest changes in steroid responsiveness of childhood nephrotic syndrome. This study was therefore undertaken to determine the features and steroid sensitivity pattern of a cohort of black children with nephrotic syndrome. Records of children managed for nephrotic syndrome from January 2008 to April 2013 were reviewed. Details including age, response to treatment, and renal histology were analysed. There were 108 children (median age: 5.9 years, peak: 1-2 years), 90.2% of whom had idiopathic nephrotic syndrome. Steroid sensitivity was 82.8% among children with idiopathic nephrotic syndrome but 75.9% overall. Median time to remission was 7 days. Median age was significantly lower in steroid sensitive compared with resistant patients. The predominant histologic finding in resistant cases was focal segmental glomerulosclerosis (53.3%). No cases of quartan malaria nephropathy or hepatitis B virus nephropathy were diagnosed. Overall mortality was 6.5%. In conclusion, unusually high steroid sensitivity is reported among a cohort of black children. This is likely attributable to the lower age structure of our cohort as well as possible changing epidemiology of some other childhood diseases. Surveillance of the epidemiology of childhood nephrotic syndrome and corresponding modifications in practice are therefore recommended.
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