ArticleAddiction & health2014
Ginger (zingiber officinale roscoe) prevents morphine-induced addictive behaviors in conditioned place preference test in rats.
Article in Addiction & health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Ginger supplementation and metabolic health: an umbrella review of meta-analyses of randomized trials.Diabetology & metabolic syndrome · 2026Review
- Investigation of the Inhibitory Effect of Naringin on the Development of Morphine Physical Dependency in Male Rats.Addiction & health · 2025Article
- Protective effects of pistachio hydroalcoholic extract on morphine-induced analgesic tolerance and dependence: investigating the impact of oxidative stress.Research in pharmaceutical sciences · 2024Article
- Can Essential Oils Provide an Alternative Adjuvant Therapy for COVID-19 Infections and Pain Management at the Same Time?Pharmaceuticals (Basel, Switzerland) · 2022Review
- The effects of ginger and its constituents in the prevention of metabolic syndrome: A review.Iranian journal of basic medical sciences · 2022Review
- Ginger Extract Reduces Chronic Morphine-Induced Neuroinflammation and Glial Activation in Nucleus Accumbens of Rats.Addiction & health · 2019Article
- Transcriptome analysis reveals the genetic basis underlying the biosynthesis of volatile oil, gingerols, and diarylheptanoids in ginger (Zingiber officinale Rosc.).Botanical studies · 2017Article
- Intervention of the Gamma-Aminobutyric Acid Type B Receptors of the Amygdala Central Nucleus on the Sensitivity of the Morphine-Induced Conditionally Preferred Location in Wistar Female Rats.Addiction & health · 2017Article
- In Vitro Effect of Zingiber officinale Extract on Growth of Streptococcus mutans and Streptococcus sanguinis.International journal of dentistry · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConsumption of chronic morphine induces neuro-inflammation and addictive seeking behavior. Ginger (Zingiber Officinale Roscoe), a well-known spice plant, has been used traditionally in the treatment of a wide variety of ailments. It has been shown that ginger has anti-inflammatory, anti-oxidative and antinociceptive properties. However, its influences on morphine-induced addictive behaviors have not yet been clarified. The aim of the present study was the inhibition of exploratory behavior of morphine addiction in the conditioned place preference test in male desert rats through ginger.
methodsFor conditioning to the morphine, the male Wistar rats received morphine (12 mg/kg intraperitoneally or i.p.) for 6 consecutive days and treatment groups were given different doses of ginger (25, 50 and 100 mg/kg intragastrically or i.g.) 30 min before morphine injection. For investigating addictive seeking behavior, conditioned place preference test (CPP) was used.
findingsOur result demonstrated that injection of morphine for 6 days induces dependency to morphine and creates addictive seeking behavior and ginger (100 mg/kg) could decrease time spend in conditioning box (addictive seeking behavior).
conclusionThe data indicated that ginger extract has a potential anti-addictive property against chronic usage of morphine.
Indexed as
Identifiers
25140219PMC4137441W2217186071What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.