Evidence map›Paper›PMID 25140208›Full record

ArticleIranian journal of basic medical sciences2014

Mild hypothermia reduces expression of Fas/FasL and MMP-3 after cerebral ischemia-reperfusion in rats.

Jingkun Zhao, Shurong Duan, Jinxia Zhou, Ruihong Sun, Liming Zhang, Desheng Wang

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Iranian journal of basic medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jingkun ZhaoDepartment of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Shurong DuanDepartment of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Jinxia ZhouPuRen Hospital of WuHan, Wu han, China.
Ruihong SunDepartment of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Liming ZhangDepartment of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Desheng WangDepartment of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Harbin Medical University · CNFirst Affiliated Hospital of Harbin Medical University · CNWuhan Puai Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the effects of local mild hypothermia on the expression of Fas, FasL and MMP-3 after cerebral ischemia-reperfusion in rats. MATERIALS AND

methodsMale Wistar rats were divided into sham-operated group (Sham), normothermia group (NT), and hypothermia group (HT). MCAO/R model was established by Longa's method, and reperfusion was allowed after 2 hr occlusion. Mild hypothermia (33±0.5°C) for 6 hr was initiated at the start of reperfusion. Immunohistochemistry was performed to determine expression Fas, FasL, and MMP-3.

resultsInfarct volume was reduced in the hypothermia group (18.43±4.23%) compared with the normothermia group (24.76±5.76%) (P<0.05). In mild hypothermia group, numbers of Fas-positive and MMP-3 positive cells were significantly less than those of normothermia group (P<0.05). Neurological functional scores of mild hypothermia were significantly improved (P<0.05).

conclusionMild hypothermia decreases infarct volume after cerebral ischemia-reperfusion, reduces Fas and MMP-3 expression, but increases FasL in cerebral ischemia-reperfusion rats.

Indexed as

Cerebral ischemia/reperfusionFasFasLHypothermiaMACO ratMMP-3

Identifiers

PMID25140208
PMCPMC4137946
OpenAlexW1583005697

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.