ArticleFrontiers in systems neuroscience2014
Speech sound discrimination training improves auditory cortex responses in a rat model of autism.
Article in Frontiers in systems neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Auditory processing in rodent models of autism: a systematic review.Journal of neurodevelopmental disorders · 2022Pooled it
- Feasibility of event-related potential (ERP) biomarker use to study effects of mother's voice exposure on speech sound differentiation of preterm infants.Developmental neuropsychology · 2018Trial
- Use of a predictor cue during a speech sound discrimination task in a Cntnap2 knockout rat model of autism.PloS one · 2025Article
- Speech paired vagus nerve stimulation restores neural sound processing in a rat model of autism.Frontiers in neuroscience · 2025Article
- Pairing tones with vagus nerve stimulation improves brain stem responses to speech in the valproic acid model of autism.Journal of neurophysiology · 2024Article
- Cortical dysmorphology and reduced cortico-collicular projections in an animal model of autism spectrum disorder.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Degraded inferior colliculus responses to complex sounds in prenatally exposed VPA rats.Journal of neurodevelopmental disorders · 2024Article
- Sex Differences in Autism Spectrum Disorder: Diagnostic, Neurobiological, and Behavioral Features.Frontiers in psychiatry · 2022Review
- Vowel speech recognition from rat electroencephalography using long short-term memory neural network.PloS one · 2022Article
- Aberrant auditory system and its developmental implications for autism.Science China. Life sciences · 2021Review
- Bridging the species gap in translational research for neurodevelopmental disorders.Neurobiology of learning and memory · 2019Article
- Shank3-deficient rats exhibit degraded cortical responses to sound.Autism research : official journal of the International Society for Autism Research · 2018Article
- Knockdown of Dyslexia-Gene Dcdc2 Interferes with Speech Sound Discrimination in Continuous Streams.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Degraded neural and behavioral processing of speech sounds in a rat model of Rett syndrome.Neurobiology of disease · 2015Article
- Prospective MEG biomarkers in ASD: pre-clinical evidence and clinical promise of electrophysiological signatures.The Yale journal of biology and medicine · 2015Review
- Speech training alters consonant and vowel responses in multiple auditory cortex fields.Behavioural brain research · 2015Article
- Temporal plasticity in auditory cortex improves neural discrimination of speech sounds.Brain stimulationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Children with autism often have language impairments and degraded cortical responses to speech. Extensive behavioral interventions can improve language outcomes and cortical responses. Prenatal exposure to the antiepileptic drug valproic acid (VPA) increases the risk for autism and language impairment. Prenatal exposure to VPA also causes weaker and delayed auditory cortex responses in rats. In this study, we document speech sound discrimination ability in VPA exposed rats and document the effect of extensive speech training on auditory cortex responses. VPA exposed rats were significantly impaired at consonant, but not vowel, discrimination. Extensive speech training resulted in both stronger and faster anterior auditory field (AAF) responses compared to untrained VPA exposed rats, and restored responses to control levels. This neural response improvement generalized to non-trained sounds. The rodent VPA model of autism may be used to improve the understanding of speech processing in autism and contribute to improving language outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.