ArticleFrontiers in neural circuits2014
Changes in complex spike activity during classical conditioning.
Article in Frontiers in neural circuits, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Cerebellar circuit computations for predictive motor control.Nature reviews. Neuroscience · 2025Review
- Early insights into eyeblink conditioning using optically pumped magnetometer-based MEG.Frontiers in human neuroscience · 2025Article
- The Effect of Nucleo-Olivary Stimulation on Climbing Fiber EPSPs in Purkinje Cells.Cerebellum (London, England) · 2024Article
- Climbing fibers provide essential instructive signals for associative learning.Nature neuroscience · 2024Article
- Cerebellar associative learning underlies skilled reach adaptation.Nature neuroscience · 2023Article
- Electrophysiological activity from over the cerebellum and cerebrum during eye blink conditioning in human subjects.Physiological reports · 2023Article
- Transcranial direct current stimulation of cerebellum alters spiking precision in cerebellar cortex: A modeling study of cellular responses.PLoS computational biology · 2021Article
- Diversity and dynamism in the cerebellum.Nature neuroscience · 2021Review
- A FN-MdV pathway and its role in cerebellar multimodular control of sensorimotor behavior.Nature communications · 2020Article
- Neuronal Activity in the Cerebellum During the Sleep-Wakefulness Transition in Mice.Neuroscience bulletin · 2020Article
- Inactivation of the interpositus nucleus during unpaired extinction does not prevent extinction of conditioned eyeblink responses or conditioning-specific reflex modification.Behavioral neuroscience · 2019Article
- Reevaluating the ability of cerebellum in associative motor learning.Scientific reports · 2019Article
- Cerebellar learning using perturbations.eLife · 2018Article
- Inactivation of the interpositus nucleus blocks the acquisition of conditioned responses and timing changes in conditioning-specific reflex modification of the rabbit eyeblink response.Neurobiology of learning and memory · 2018Article
- Purkinje cell BKchannel ablation induces abnormal rhythm in deep cerebellar nuclei and prevents LTD.Scientific reports · 2018Article
- Article
- The dynamic relationship between cerebellar Purkinje cell simple spikes and the spikelet number of complex spikes.The Journal of physiology · 2017Article
- Are Purkinje Cell Pauses Drivers of Classically Conditioned Blink Responses?Cerebellum (London, England) · 2016Review
- Cerebellar contributions to motor control and language comprehension: searching for common computational principles.Annals of the New York Academy of Sciences · 2016Review
- Evolving Models of Pavlovian Conditioning: Cerebellar Cortical Dynamics in Awake Behaving Mice.Cell reports · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cerebellar cortex is necessary for adaptively timed conditioned responses (CRs) in eyeblink conditioning. During conditioning, Purkinje cells acquire pause responses or "Purkinje cell CRs" to the conditioned stimuli (CS), resulting in disinhibition of the cerebellar nuclei (CN), allowing them to activate motor nuclei that control eyeblinks. This disinhibition also causes inhibition of the inferior olive (IO), via the nucleo-olivary pathway (N-O). Activation of the IO, which relays the unconditional stimulus (US) to the cortex, elicits characteristic complex spikes in Purkinje cells. Although Purkinje cell activity, as well as stimulation of the CN, is known to influence IO activity, much remains to be learned about the way that learned changes in simple spike firing affects the IO. In the present study, we analyzed changes in simple and complex spike firing, in extracellular Purkinje cell records, from the C3 zone, in decerebrate ferrets undergoing training in a conditioning paradigm. In agreement with the N-O feedback hypothesis, acquisition resulted in a gradual decrease in complex spike activity during the conditioned stimulus, with a delay that is consistent with the long N-O latency. Also supporting the feedback hypothesis, training with a short interstimulus interval (ISI), which does not lead to acquisition of a Purkinje cell CR, did not cause a suppression of complex spike activity. In contrast, observations that extinction did not lead to a recovery in complex spike activity and the irregular patterns of simple and complex spike activity after the conditioned stimulus are less conclusive.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.