Evidence map›Paper›PMID 25140047›Full record

Trial reportSocial cognitive and affective neuroscience2015

Oxytocin tempers calculated greed but not impulsive defense in predator-prey contests.

Carsten K W De Dreu, H Steven Scholte, Frans A A M van Winden, K Richard Ridderinkhof

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Social cognitive and affective neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
6.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 40 citations in OpenAlex.

  1. Trial
  2. Article
  3. The nasty neighbor effect in humans.Science advances · 2024
    Article
  4. Article
  5. Political games of attack and defence.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021
    Review
  6. Article
  7. In-group defense, out-group aggression, and coordination failures in intergroup conflict.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
  8. Article
  9. Opposing Oxytocin Effects on Intergroup Cooperative Behavior in Intuitive and Reflective Minds.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Carsten K W De DreuDepartment of Psychology, University of Amsterdam, 1018 XA Amsterdam, The Netherlands, Amsterdam Brain and Cognition (ABC), University of Amsterdam, 1018 VZ Amsterdam, The Netherlands, and CREED - Amsterdam School of Economics, University of Amsterdam, 1018 WB Amsterdam, The Netherlands Department of Psychology, University of Amsterdam, 1018 XA Amsterdam, The Netherlands, Amsterdam Brain and Cognition (ABC), University of Amsterdam, 1018 VZ Amsterdam, The Netherlands, and CREED - Amsterdam School of Economics, University of Amsterdam, 1018 WB Amsterdam, The Netherlands Department of Psychology, University of Amsterdam, 1018 XA Amsterdam, The Netherlands, Amsterdam Brain and Cognition (ABC), University of Amsterdam, 1018 VZ Amsterdam, The Netherlands, and CREED - Amsterdam School of Economics, University of Amsterdam, 1018 WB Amsterdam, The Netherlands c.k.w.dedreu@uva.nl.
H Steven ScholteDepartment of Psychology, University of Amsterdam, 1018 XA Amsterdam, The Netherlands, Amsterdam Brain and Cognition (ABC), University of Amsterdam, 1018 VZ Amsterdam, The Netherlands, and CREED - Amsterdam School of Economics, University of Amsterdam, 1018 WB Amsterdam, The Netherlands Department of Psychology, University of Amsterdam, 1018 XA Amsterdam, The Netherlands, Amsterdam Brain and Cognition (ABC), University of Amsterdam, 1018 VZ Amsterdam, The Netherlands, and CREED - Amsterdam School of Economics, University of Amsterdam, 1018 WB Amsterdam, The Netherlands.
Frans A A M van WindenDepartment of Psychology, University of Amsterdam, 1018 XA Amsterdam, The Netherlands, Amsterdam Brain and Cognition (ABC), University of Amsterdam, 1018 VZ Amsterdam, The Netherlands, and CREED - Amsterdam School of Economics, University of Amsterdam, 1018 WB Amsterdam, The Netherlands Department of Psychology, University of Amsterdam, 1018 XA Amsterdam, The Netherlands, Amsterdam Brain and Cognition (ABC), University of Amsterdam, 1018 VZ Amsterdam, The Netherlands, and CREED - Amsterdam School of Economics, University of Amsterdam, 1018 WB Amsterdam, The Netherlands.
K Richard RidderinkhofDepartment of Psychology, University of Amsterdam, 1018 XA Amsterdam, The Netherlands, Amsterdam Brain and Cognition (ABC), University of Amsterdam, 1018 VZ Amsterdam, The Netherlands, and CREED - Amsterdam School of Economics, University of Amsterdam, 1018 WB Amsterdam, The Netherlands Department of Psychology, University of Amsterdam, 1018 XA Amsterdam, The Netherlands, Amsterdam Brain and Cognition (ABC), University of Amsterdam, 1018 VZ Amsterdam, The Netherlands, and CREED - Amsterdam School of Economics, University of Amsterdam, 1018 WB Amsterdam, The Netherlands.
Amsterdam University of the Arts · NLUniversity of Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human cooperation and competition is modulated by oxytocin, a hypothalamic neuropeptide that functions as both hormone and neurotransmitter. Oxytocin's functions can be captured in two explanatory yet largely contradictory frameworks: the fear-dampening (FD) hypothesis that oxytocin has anxiolytic effects and reduces fear-motivated action; and the social approach/avoidance (SAA) hypothesis that oxytocin increases cooperative approach and facilitates protection against aversive stimuli and threat. We tested derivations from both frameworks in a novel predator-prey contest game. Healthy males given oxytocin or placebo invested as predator to win their prey's endowment, or as prey to protect their endowment against predation. Neural activity was registered using 3T-MRI. In prey, (fear-motivated) investments were fast and conditioned on the amygdala. Inconsistent with FD, oxytocin did not modulate neural and behavioral responding in prey. In predators, (greed-motivated) investments were slower, and conditioned on the superior frontal gyrus (SFG). Consistent with SAA, oxytocin reduced predator investment, time to decide and activation in SFG. Thus, whereas oxytocin does not incapacitate the impulsive ability to protect and defend oneself, it lowers the greedy and more calculated appetite for coming out ahead.

Indexed as

Cooperative BehaviorAdministration, IntranasalAdultAggressionAnimalsCross-Over StudiesDouble-Blind MethodExecutive FunctionHumansImpulsive BehaviorMagnetic Resonance ImagingMaleMotivationOxytocinPredatory BehaviorSocial BehaviorOxytocinaggressionapproach motivationcooperationendocrinologyexecutive control

Identifiers

PMID25140047
PMCPMC4420750
OpenAlexW1983463081

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.