Evidence map›Paper›PMID 25139997›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2014

Refilling drug delivery depots through the blood.

Yevgeny Brudno, Eduardo A Silva, Cathal J Kearney, Sarah A Lewin, Alex Miller, Kathleen D Martinick, Michael Aizenberg, David J Mooney

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. DNA-directed assembly of multivalent lipid nanoparticles for targeted T cell gene delivery.Journal of controlled release : official journal of the Controlled Release Society · 2026
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  16. Bioorthogonal chemistry.Nature reviews. Methods primers · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Yevgeny BrudnoWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115; School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138;
Eduardo A SilvaWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115; School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138; Department of Biomedical Engineering, University of California, Davis, CA 95616; and.
Cathal J KearneyWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115; School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138; Department of Anatomy, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
Sarah A LewinWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115;
Alex MillerSchool of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138;
Kathleen D MartinickWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115;
Michael AizenbergWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115;
David J MooneyWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115; School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138; mooneyd@seas.harvard.edu.

Funding

Biomaterial based breast cancer vaccineR01EB015498 · NIBIB · HARVARD MEDICAL SCHOOL · PI MOONEY, DAVID J · 2013 to 2016
$1.5M
NIBIB NIH HHS R01 EB015498
6 · The paper itself

Abstract

Local drug delivery depots have significant clinical utility, but there is currently no noninvasive technique to refill these systems once their payload is exhausted. Inspired by the ability of nanotherapeutics to target specific tissues, we hypothesized that blood-borne drug payloads could be modified to home to and refill hydrogel drug delivery systems. To address this possibility, hydrogels were modified with oligodeoxynucleotides (ODNs) that provide a target for drug payloads in the form of free alginate strands carrying complementary ODNs. Coupling ODNs to alginate strands led to specific binding to complementary-ODN-carrying alginate gels in vitro and to injected gels in vivo. When coupled to a drug payload, sequence-targeted refilling of a delivery depot consisting of intratumor hydrogels completely abrogated tumor growth. These results suggest a new paradigm for nanotherapeutic drug delivery, and this concept is expected to have applications in refilling drug depots in cancer therapy, wound healing, and drug-eluting vascular grafts and stents.

Indexed as

AlginatesAnimalsAntibiotics, AntineoplasticBreast NeoplasmsDisease Models, AnimalDoxorubicinDrug Delivery SystemsGlucuronic AcidHexuronic AcidsHumansHydrazonesHydrogelsInjections, IntralesionalInjections, IntravenousMelanoma, ExperimentalMiceAlginatesAntibiotics, AntineoplasticDoxorubicinGlucuronic AcidHexuronic AcidsHydrazonesHydrogelsOligodeoxyribonucleotidesbiomaterialscontrolled releaseDNA nanotechnologynanoparticletargeting

Identifiers

PMID25139997
PMCPMC4156738

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.