ArticleProceedings of the National Academy of Sciences of the United States of America2014
Interlamellar CA1 network in the hippocampus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- The ventral hippocampus: computations, circuits and functions.Nature reviews. Neuroscience · 2026Review
- HDAC3 Mediates Hippocampal Microglial Pyroptosis Via the STING/NLRP3 Pathway and Contributes To Cognitive Impairment in Sepsis-Associated Encephalopathy.Inflammation · 2026Article
- Review
- Hippocampal sequences represent working memory and implicit timing.Cell reports · 2025Article
- Differentiated Presynaptic Input to OLMɑ2 Cells Along the Hippocampal Dorsoventral Axis: Implications for Hippocampal Microcircuit Function.Hippocampus · 2025Article
- Mesoscale connectivity of the human hippocampus and fimbria revealed by ex vivo diffusion MRI.NeuroImage · 2025Article
- KThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Opposite serotonergic modulation of sharp waves in the dorsal and ventral hippocampus.Frontiers in synaptic neuroscience · 2025Article
- STING Driving Synaptic Phagocytosis of Hippocampal Microglia/Macrophages Contributes to Cognitive Impairment in Sepsis-Associated Encephalopathy in Mice.CNS neuroscience & therapeutics · 2024Article
- Community-based reconstruction and simulation of a full-scale model of the rat hippocampus CA1 region.PLoS biology · 2024Article
- Early hippocampal hyperexcitability and synaptic reorganization in mouse models of amyloidosis.iScience · 2024Article
- Differences in the consolidation by spontaneous and evoked ripples in the presence of active dendrites.PLoS computational biology · 2024Article
- Activation of feedforward wiring in adult hippocampal neurons by the basic-helix-loop-helix transcription factor Ascl4.PNAS nexus · 2024Article
- Silencing CA1 pyramidal cells output reveals the role of feedback inhibition in hippocampal oscillations.Nature communications · 2024Article
- Increased Interhemispheric Connectivity of a Distinct Type of Hippocampal Pyramidal Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Gamma oscillation plasticity is mediated via parvalbumin interneurons.Science advances · 2024Article
- Article
- Memory consolidation from a reinforcement learning perspective.Frontiers in computational neuroscience · 2024Article
- Mapping mesoscale connectivity within the human hippocampus.NeuroImage · 2023Article
- Spike-based coupling between single neurons and populations across rat sensory cortices, perirhinal cortex, and hippocampus.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
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8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To understand the cellular basis of learning and memory, the neurophysiology of the hippocampus has been largely examined in thin transverse slice preparations. However, the synaptic architecture along the longitudinal septo-temporal axis perpendicular to the transverse projections in CA1 is largely unknown, despite its potential significance for understanding the information processing carried out by the hippocampus. Here, using a battery of powerful techniques, including 3D digital holography and focal glutamate uncaging, voltage-sensitive dye, two-photon imaging, electrophysiology, and immunohistochemistry, we show that CA1 pyramidal neurons are connected to one another in an associational and well-organized fashion along the longitudinal axis of the hippocampus. Such CA1 longitudinal connections mediate reliable signal transfer among the pyramidal cells and express significant synaptic plasticity. These results illustrate a need to reconceptualize hippocampal CA1 network function to include not only processing in the transverse plane, but also operations made possible by the longitudinal network. Our data will thus provide an essential basis for future computational modeling studies on information processing operations carried out in the full 3D hippocampal network that underlies its complex cognitive functions.
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