Evidence map›Paper›PMID 25139979›Full record

Trial reportJPEN. Journal of parenteral and enteral nutrition2016

Effect of High-Dose Cysteine Supplementation on Erythrocyte Glutathione: A Double-Blinded, Randomized Placebo-Controlled Pilot Study in Critically Ill Neonates.

Kara L Calkins, Lauren A Sanchez, Chi-Hong Tseng, Kym F Faull, Alexander J Yoon, Christopher M Ryan, Thuc Le, Stephen B Shew

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in JPEN. Journal of parenteral and enteral nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Kara L CalkinsDepartment of Pediatrics, Division of Neonatology and Developmental Biology, Neonatal Research Center, David Geffen School of Medicine, University of California, Los Angeles, and Mattel Children's Hospital at UCLA, Los Angeles, California.
Lauren A SanchezDepartment of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, and Mattel Children's Hospital at UCLA, Los Angeles, California.
Chi-Hong TsengDepartment of Medicine, Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine, University of California, Los Angeles, and Mattel Children's Hospital at UCLA, Los Angeles, California.
Kym F FaullPasarow Mass Spectrometry Laboratory, Department of Psychiatry, David Geffen School of Medicine, University of California, Los Angeles, and Mattel Children's Hospital at UCLA, Los Angeles, California.
Alexander J YoonPasarow Mass Spectrometry Laboratory, Department of Psychiatry, David Geffen School of Medicine, University of California, Los Angeles, and Mattel Children's Hospital at UCLA, Los Angeles, California.
Christopher M RyanPasarow Mass Spectrometry Laboratory, Department of Psychiatry, David Geffen School of Medicine, University of California, Los Angeles, and Mattel Children's Hospital at UCLA, Los Angeles, California.
Thuc LePasarow Mass Spectrometry Laboratory, Department of Psychiatry, David Geffen School of Medicine, University of California, Los Angeles, and Mattel Children's Hospital at UCLA, Los Angeles, California.
Stephen B ShewDepartment of Surgery, Division of Pediatric Surgery, David Geffen School of Medicine, University of California, Los Angeles, and Mattel Children's Hospital at UCLA, Los Angeles, California SShew@mednet.ucla.edu.
Mattel Children's Hospital · USUniversity of California, Los Angeles · US

Funding

ZDV &3TC NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFECTED INFANTS &M01RR000865 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WASHINGTON, ARNOLD E. · 1985 to 2011
$43.4M
Building Interdisciplinary Research Careers in Women's Health (BIRCWH) CenterK12HD001400 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHAUDHURI, GAUTAM · 2000 to 2009
$4.2M
TRAINING IN NEONATAL AND DEVELOPMENTAL DISEASEST32HD007549 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEVASKAR, SHERIN U · 2001 to 2010
$3.2M
Effect of cysteine on glutathione production in critically ill neonatesK08HD052885 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHEW, STEPHEN · 2006 to 2010
$609k
NCRR NIH HHS M01 RR000865NCRR NIH HHS M01-RR00865NICHD NIH HHS K08 HD052885NICHD NIH HHS K08HD052885NICHD NIH HHS K12HD00140NICHD NIH HHS K12 HD001400NICHD NIH HHS L40 HD051420NICHD NIH HHS T32 HD007549NICHD NIH HHS T32HD07549
6 · The paper itself

Abstract

backgroundThis study's objective was to determine if parenteral cysteine when compared with isonitrogenous noncysteine supplementation increases erythrocyte reduced glutathione (GSH) in neonates at high risk for inflammatory injury. MATERIAL AND

methodsNeonates with a score for neonatal acute physiology >10 requiring mechanical ventilation and parenteral nutrition (PN) were randomized in a double-blinded, placebo-controlled study to receive parenteral cysteine-HCl (CYS group) or additional PN amino acids (ISO group) at 121 mg/kg/d for ≥7 days. A 6-hour [(13)C2] glycine IV infusion was administered at study week 1 to determine the fractional synthetic rate of GSH (FSR-GSH).

resultsBaseline characteristics were similar between the CYS (n = 17) and ISO groups (n = 21). Erythrocyte GSH and total glutathione concentrations, GSH:oxidized GSH (GSSG), and FSR-GSH after treatment were not different between groups. However, the CYS group had a larger individual positive change in GSH and total glutathione (infusion day - baseline) compared with the ISO group (P = .02 for each). After adjusting for treatment, a lower enrollment weight and rate of red blood cell transfusion were associated with a decreased change in total glutathione and GSH (P < .05 for each).

conclusionWhen compared with isonitrogenous noncysteine supplementation, high-dose cysteine supplementation for at least 1 week in critically ill neonates resulted in a larger and more positive individual change in GSH. Smaller infants and those who received transfused blood demonstrated less effective change in GSH with cysteine supplementation. The benefit of cysteine remains promising and deserves further investigation.

Indexed as

Amino AcidsChronic DiseaseCritical IllnessCysteineDietary SupplementsDose-Response Relationship, DrugDouble-Blind MethodErythrocytesFemaleGlutathioneGlycineHumansInfant, NewbornInterleukin-6Linear ModelsLung DiseasesAmino AcidsCysteineGlutathioneGlycineInterleukin-6antioxidantchronic lung diseaseinflammationneonatesparenteral nutritionprematurityred blood cell

Identifiers

PMID25139979
PMCPMC4573914
OpenAlexW1966870681

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.