ArticleeLife2014
A suppression hierarchy among competing motor programs drives sequential grooming in Drosophila.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers.
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Who cites it
117 citing papers in PubMed.
- Motor neurons organize Drosophila feeding sequences via a disinhibitory cascade.Nature neuroscience · 2026Article
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- Whole-body 3D kinematics of freely behavingbioRxiv : the preprint server for biology · 2026Article
- Centralized brain networks controlling antennal grooming coordination.Nature communications · 2026Article
- Mechanisms that create a sequence of feeding-related behaviors in the molluskJournal of neurophysiology · 2026Article
- Segmentally repeated ventral nerve cord circuits drive different leg rubbing behaviors iniScience · 2026Article
- Inhibitory circuits control leg movements duringeLife · 2026Article
- Encoding of movement primitives and body posture through distributed proprioception in walking and climbing insects.Biological cybernetics · 2026Article
- DANCE provides an open-source and low-cost approach to quantify aggression and courtship ineLife · 2025Article
- Behavior choices amongst grooming, feeding and courting in Drosophila show contextual flexibility, not an absolute hierarchy of needs.The Journal of experimental biology · 2025Article
- Inhibitory circuits control leg movements duringbioRxiv : the preprint server for biology · 2025Article
- Supraspinal commands have a modular organization that is behavioral context specific.Current biology : CB · 2025Article
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- Embedding stochastic dynamics of the environment in spontaneous activity by prediction-based plasticity.eLife · 2025Article
- Neurofibromin Deficiency Alters the Patterning and Prioritization of Motor Behaviors in a State-Dependent Manner.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Statistical signature of subtle behavioral changes in large-scale assays.PLoS computational biology · 2025Article
- Decoding neuronal wiring by joint inference of cell identity and synaptic connectivity.bioRxiv : the preprint server for biology · 2025Article
- Single-cell type analysis of wing premotor circuits in the ventral nerve cord ofbioRxiv : the preprint server for biology · 2025Article
- Capturing continuous, long timescale behavioral changes in Drosophila melanogaster postural data.PLoS computational biology · 2025Article
- A phylogenetic analysis of the CDKL protein family unravels its evolutionary history and supports theFrontiers in cell and developmental biology · 2025Article
57 more citing papers are in PubMed but not listed here.
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7 authors.
Funding
Abstract
Motor sequences are formed through the serial execution of different movements, but how nervous systems implement this process remains largely unknown. We determined the organizational principles governing how dirty fruit flies groom their bodies with sequential movements. Using genetically targeted activation of neural subsets, we drove distinct motor programs that clean individual body parts. This enabled competition experiments revealing that the motor programs are organized into a suppression hierarchy; motor programs that occur first suppress those that occur later. Cleaning one body part reduces the sensory drive to its motor program, which relieves suppression of the next movement, allowing the grooming sequence to progress down the hierarchy. A model featuring independently evoked cleaning movements activated in parallel, but selected serially through hierarchical suppression, was successful in reproducing the grooming sequence. This provides the first example of an innate motor sequence implemented by the prevailing model for generating human action sequences.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.