ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2014
Comparison of mammographic density assessed as volumes and areas among women undergoing diagnostic image-guided breast biopsy.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00475761 (Breast Radiology Evaluation and Study of Tissues), which is not on this map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Breast Radiology Evaluation and Study of Tissues (Breast) Stamp Project
Who cites it
22 citing papers in PubMed.
- Associations of local breast density with patient characteristics and risk of breast cancer among women undergoing diagnostic breast biopsy.Breast cancer research : BCR · 2026Article
- Unraveling the role of stromal disruption in aggressive breast cancer etiology and outcomes.Journal of the National Cancer Institute · 2025Article
- Mammary collagen architecture and its association with mammographic density and lesion severity among women undergoing image-guided breast biopsy.Breast cancer research : BCR · 2021Article
- Relationship of Serum Progesterone and Progesterone Metabolites with Mammographic Breast Density and Terminal Ductal Lobular Unit Involution among Women Undergoing Diagnostic Breast Biopsy.Journal of clinical medicine · 2020Article
- Polygenic risk score for the prediction of breast cancer is related to lesser terminal duct lobular unit involution of the breast.NPJ breast cancer · 2020Article
- Using Digital Pathology to Understand Epithelial Characteristics of Benign Breast Disease among Women Undergoing Diagnostic Image-Guided Breast Biopsy.Cancer prevention research (Philadelphia, Pa.) · 2019Observational
- Relationship of circulating insulin-like growth factor-I and binding proteins 1-7 with mammographic density among women undergoing image-guided diagnostic breast biopsy.Breast cancer research : BCR · 2019Article
- Application of convolutional neural networks to breast biopsies to delineate tissue correlates of mammographic breast density.NPJ breast cancer · 2019Article
- Using deep convolutional neural networks to identify and classify tumor-associated stroma in diagnostic breast biopsies.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018Article
- Adiposity, breast density, and breast cancer risk: epidemiological and biological considerations.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2017Review
- DEEP LEARNING-BASED ASSESSMENT OF TUMOR-ASSOCIATED STROMA FOR DIAGNOSING BREAST CANCER IN HISTOPATHOLOGY IMAGES.Proceedings. IEEE International Symposium on Biomedical Imaging · 2017Article
- Association between breast cancer genetic susceptibility variants and terminal duct lobular unit involution of the breast.International journal of cancer · 2017Article
- Relation of Serum Estrogen Metabolites with Terminal Duct Lobular Unit Involution Among Women Undergoing Diagnostic Image-Guided Breast Biopsy.Hormones & cancer · 2016Article
- Relationships between mammographic density, tissue microvessel density, and breast biopsy diagnosis.Breast cancer research : BCR · 2016Article
- Ages at menarche- and menopause-related genetic variants in relation to terminal duct lobular unit involution in normal breast tissue.Breast cancer research and treatment · 2016Article
- Circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3 and terminal duct lobular unit involution of the breast: a cross-sectional study of women with benign breast disease.Breast cancer research : BCR · 2016Article
- Relationship of Terminal Duct Lobular Unit Involution of the Breast with Area and Volume Mammographic Densities.Cancer prevention research (Philadelphia, Pa.) · 2016Article
- The effect of change in body mass index on volumetric measures of mammographic density.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2015Article
- Article
- Relationship of serum estrogens and metabolites with area and volume mammographic densities.Hormones & cancer · 2015Article
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Authors and funding
15 authors.
Funding
Abstract
backgroundMammographic density (MD), the area of non-fatty-appearing tissue divided by total breast area, is a strong breast cancer risk factor. Most MD analyses have used visual categorizations or computer-assisted quantification, which ignore breast thickness. We explored MD volume and area, using a volumetric approach previously validated as predictive of breast cancer risk, in relation to risk factors among women undergoing breast biopsy.
methodsAmong 413 primarily white women, ages 40 to 65 years, undergoing diagnostic breast biopsies between 2007 and 2010 at an academic facility in Vermont, MD volume (cm(3)) was quantified in craniocaudal views of the breast contralateral to the biopsy target using a density phantom, whereas MD area (cm(2)) was measured on the same digital mammograms using thresholding software. Risk factor associations with continuous MD measurements were evaluated using linear regression.
resultsPercent MD volume and area were correlated (r = 0.81) and strongly and inversely associated with age, body mass index (BMI), and menopause. Both measures were inversely associated with smoking and positively associated with breast biopsy history. Absolute MD measures were correlated (r = 0.46) and inversely related to age and menopause. Whereas absolute dense area was inversely associated with BMI, absolute dense volume was positively associated.
conclusionsVolume and area MD measures exhibit some overlap in risk factor associations, but divergence as well, particularly for BMI. IMPACT: Findings suggest that volume and area density measures differ in subsets of women; notably, among obese women, absolute density was higher with volumetric methods, suggesting that breast cancer risk assessments may vary for these techniques.
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